Liquid Crystal Polymer Substrate IntraCochlear Electrode

液晶聚合物基底耳蜗内电极

• 批准号: 6585330
• 负责人: DAVID J EDELL
• 金额: $ 11.56万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-10 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585330
• 关键词: animal tissue; biological models; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; cochlear implants; electrical property; electrodes; electrophysiology; human tissue; liquid crystal; medical implant science; neural conduction; polymers; telemetry; tympanum

DESCRIPTION (provided by applicant): This is a technology development proposal that will create a new technology base for cochlear electrodes. The goal is to produce a micro-machined, multi-contact electrode array using a biocompatible, bioresistant, dimensionally stable, polymer substrate Because this polymer substrate is dimensionally stable, thin metal traces can be micro-machined for electrode contacts and interconnects The resulting electrode array can be as thin as 25mm, less than 0 5mm wide and very flexible. With this small, flexible array as a beginning point, the mechanical aspects at every point along the length of the complete intra-cochlear implant can be specified and optimized. These mechanical characteristics of shape, springiness, and flexibility in two planes determine the probability of trauma during surgical insertion. Thus, an electrode with idealized mechanical properties will result in less trauma Benefits of this new technology would also include improved electrode positioning necessary for more efficient coupling to the residual neural elements, a larger number of electrode contacts and possibly deeper insertion into the lower frequency portions of the cochlea. Goals of Phase I are design and fabrication of several iterations of electrode carriers and electrode arrays, mechanical structuring of the arrays, and saline soak testing for electrical properties. In preparation for Phase II, an implantable integrated circuit diagnostic stimulator for detailed study of the assembly stability under realistic chronic implant conditions in-vitro and in-vivo will be developed. Phase II research will involve further optimization of the intracochlear electrode arrays based on results of extensive in-vivo measurements of performance using CNS recording paradigms at UCSF and analysis of insertion trauma in cat and human cadaver material. Long-term reliability of the technology will be evaluated in-vitro and in-vivo using the implantable diagnostic stimulator. An integrated circuit stimulator will be developed based on results of the diagnostic stimulator and embedded within the terminal portion of the polymer substrate. This new, robust, intracochlear implant will be useful for advanced chronic physiology studies and clinical application.

描述（由申请人提供）：这是一项技术开发提案，将为耳蜗电极创建新的技术基础。目标是使用生物相容性、生物抗性、尺寸稳定的聚合物基底来生产微机械加工的多触点电极阵列。因为该聚合物基底是尺寸稳定的，所以可以对薄金属迹线进行微机械加工以用于电极触点和互连。所得到的电极阵列可以薄至25mm，宽度小于0.5mm并且非常柔性。以该小的柔性阵列作为起点，可以指定和优化沿着完整耳蜗内植入物的长度的沿着每个点处的机械方面。两个平面中的形状、弹性和柔韧性的这些机械特性决定了手术插入期间创伤的可能性。因此，具有理想化机械特性的电极将导致较少的创伤。这种新技术的益处还将包括更有效地耦合到残余神经元件所需的改进的电极定位、更大数量的电极接触以及可能更深地插入耳蜗的较低频率部分。第一阶段的目标是设计和制造电极载体和电极阵列的几个迭代，阵列的机械结构，以及电性能的盐水浸泡测试。在第二阶段的准备中，将开发一种植入式集成电路诊断刺激器，用于详细研究在体外和体内实际慢性植入条件下的组装稳定性。第二阶段研究将涉及进一步优化颅内电极阵列的基础上，广泛的体内性能测量的结果，使用中枢神经系统记录范例在加州大学旧金山分校和分析插入创伤的猫和人的尸体材料。将使用植入式诊断刺激器在体外和体内评价该技术的长期可靠性。将根据诊断刺激器的结果开发集成电路刺激器，并将其嵌入聚合物基板的端子部分中。这种新的，坚固的，脑内植入物将有助于先进的慢性生理学研究和临床应用。