PhysioTelemeter for Autonomic Monitoring

用于自主监测的 PhysioTelemeter

• 批准号: 6963693
• 负责人: DAVID J EDELL
• 金额: $ 14.88万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6963693
• 关键词: autonomic disorder; autonomic nervous system; biomedical device power system; biomedical equipment development; biosensor device; clinical research; diabetes mellitus; diabetic neuropathy; human subject; neuropathology; neurophysiology; patient monitoring device; spinal cord injury; telemetry

DESCRIPTION (provided by applicant): A "PhysioTelemeter(tm)" system for physiological research and clinical monitoring of autonomic nervous system function in Spinal Cord Injury (SCI) and Diabetes is proposed. The system will allow non-invasive, unobtrusive, wireless monitoring of multiple physiological variables at multiple locations where long term use or freedom of movement is desirable. The Phase-1 system will consist of 3 battery powered PhysioTelemeters(tm), each transmitting on a unique radio frequency to a remote receiver and a computer for display and archive. Each telemeter will transmit data from 4 exemplary sensors (bioelectric, temperature, vibration and battery voltage) up to 10M in distance. The Phase-1 telemeters will be approximately the diameter and weight of a US quarter, but twice as thick, and will operate for over 8 hours from a lithium coin cell battery. This small size and light weight will allow measurements in active subjects with the PhysioTelemeters(tm) temporarily adhered to the skin over the regions of interest. Clinical collaborators for Phase-1 include a Physical Medicine and Rehabilitation clinician with expertise in SCI pathophysiology, and a physiologist with clinical expertise in dysautonomia in patients with diabetes. These collaborators will review and critique the technology at various stages to guide the technology, and will evaluate the system with limited human testing on healthy subjects in preparation for Phase-2, During Phase-2, clinical collaborators will utilize the Phase-1 prototype system extensively to determine the practical utility of the approach in their clinical practice and research. Two active measurements (skin perfusion and impedance) will be added. The system will be further optimized including use of custom integrated circuits to decrease size and power, increasing the range to 30M, adding 5 more frequency channels for a total of 8, developing an environmentally resistant package, and providing a rechargeable battery system.

描述（由申请人提供）：提出了一种用于脊髓损伤（SCI）和糖尿病中自主神经系统功能的生理研究和临床监测的“PhysioTelemeter（tm）”系统。该系统将允许在需要长期使用或自由活动的多个位置对多个生理变量进行非侵入性、不引人注目的无线监测。 第一阶段系统将由 3 个电池供电的 PhysioTelemeters(tm) 组成，每个 PhysioTelemeters 以独特的射频传输到远程接收器和计算机以进行显示和存档。 每个遥测仪将从 4 个典型传感器（生物电、温度、振动和电池电压）传输数据，传输距离最远可达 10M。 Phase-1 遥测仪的直径和重量约为美国 25 美分硬币的直径和重量，但厚度是其两倍，并且可使用纽扣锂电池供电超过 8 小时。这种小尺寸和轻重量允许使用暂时粘附在感兴趣区域皮肤上的 PhysioTelemeters(tm) 对活跃受试者进行测量。 第一阶段的临床合作者包括一名具有 SCI 病理生理学专业知识的物理医学和康复临床医生，以及一名具有糖尿病患者自主神经功能障碍临床专业知识的生理学家。这些合作者将在各个阶段审查和批评该技术以指导该技术，并将通过对健康受试者进行有限的人体测试来评估该系统，为第二阶段做准备， 在第二阶段期间，临床合作者将广泛利用第一阶段原型系统来确定该方法在其临床实践和研究中的实际效用。将添加两个主动测量（皮肤灌注和阻抗）。该系统将进一步优化，包括使用定制集成电路来减小尺寸和功耗、将范围增加到 30M、增加 5 个频率通道（总共 8 个）、开发耐环境封装以及提供可充电电池系统。