Ultra-low-power wireless implant stimulator for prosthesis sensory feedback

用于假体感觉反馈的超低功耗无线植入刺激器

• 批准号: 7167163
• 负责人: DAVID J EDELL
• 金额: $ 14.79万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7167163
• 关键词: amputation; biomedical equipment development; clinical research; electromyography; functional ability; human subject; implant; limbs; microelectrodes; neuromuscular stimulator; portable biomedical equipment; prosthesis; quality of life; sensory feedback; telemetry

DESCRIPTION (provided by applicant): Project Summary/Abstract: It is widely recognized that the functionality and user acceptance of prosthetic limbs would be improved by providing sensory feedback. This project aims to develop tiny button-like stimulator modules (OptiStims) which can be implanted subdermally to provide electrocutaneous based sensory feedback. The mechanical characteristics of the assembly will be similar to that of the skin to ensure stability and comfort. These OptiStims will be ultra-low power (a few microwatts) single channel devices that are individually RF powered and optically controlled transcutaneously from transmitters in the prosthesis shell. The stimulator circuitry is based on a proprietary, innovative design using technology concepts previously developed over the past 15 years at InnerSea Technology for implantable EMG telemetry. Because of the modular design, the stimulators can be placed in arbitrary locations to form customized spatial arrays for feedback strategies. The control and artificial sensor systems will be readily incorporated into presently available myoelectric arms. The Phase 1 system will be fabricated using discrete components. It will consist of a stimulator package with an attached concentric ring electrode surrounded by a thin flexible silicone. During Phase 2, an integrated circuit would be developed so that the stimulator electronics platform (ca, 2x2mm) could be merged with the electrode components to achieve a tiny, soft, disk structure approximately 6 mm diameter and 2mm thick. Subcutaneous implantation will be a simple outpatient procedure. There has been extensive prior work in developing electrotactile systems for sensory substitution that demonstrated the effectiveness of this communication strategy. The envisioned feedback system represents a considerably less invasive approach than electrical interfaces to peripheral nerves. At the same time, subdermal stimulation provides several advantages over non-invasive cutaneous communication strategies that use surface electrodes or vibrotactors. These include better stimulus localization and more consistent sensation both in regard to the quality of the sensation and its perceived intensity. More consistent sensation derives from greater immunity to variations in skin surface coupling parameters associated with surface electrodes including location, degree of hydration, pores, and contact pressure. Sensory information that will initially be targeted include: grasp force, object slippage and wrist. The Specific Aim of PHASE 1 is to develop the OptiStims and show the feasibility of the approach in 1 below elbow amputee subject fitted with a functional 2 channel sensory feedback system. Project Narrative: Under SBIR Phase II funding, an implantable EMG telemeter is being developed. Together with the Phase II OptiStim, it will be possible to fit amputees with closed loop control using stable sources of EMG, and feedback of sensation through stable skin neurostimulation. The functionality of prosthetic limbs will be enhanced to improve quality of life and employment opportunities for veteran and civilian amputees alike.

描述（由申请人提供）：项目摘要/摘要：广泛认识到，通过提供感官反馈，可以改善对假肢的功能和用户接受。该项目旨在开发类似纽扣的微型刺激器模块（Optistims），可以在下植入以提供基于电视脉的感觉反馈。组件的机械特性将与皮肤的机械特性相似，以确保稳定性和舒适性。这些Optistims将是单个通道设备的超低功率（几微米），它们是单独的RF供电并从假体外壳中的发射机经智能控制的。刺激器电路基于一种专有，创新的设计，该设计使用了过去15年来在Inlersea Technology的植入式EMG遥测中开发的技术概念。由于模块化设计，可以将刺激器放置在任意位置，以形成自定义的空间阵列以进行反馈策略。控制和人造传感器系统将很容易被整合到目前可用的肌电臂中。第1阶段系统将使用离散组件制造。它将由一个刺激器包装，其中包含薄柔性有机硅的附着的同心环电极。在第2阶段，将开发一个集成的电路，以便可以将刺激器电子平台（CA，2x2mm）与电极组合合并，以实现大小，柔软的磁盘结构，直径约为6 mm，厚度为2mm。皮下植入将是一个简单的门诊手术。在开发用于替代的电动系统方面，已经进行了广泛的工作，这些系统证明了这种交流策略的有效性。所设想的反馈系统比对周围神经的电界面所代表的侵入性方法要少得多。同时，与使用表面电极或纤维触角的非侵入性皮肤通信策略相比，下刺激具有多个优势。这些在感觉质量及其感知强度方面包括更好的刺激定位和更一致的感觉。更一致的感觉来自于与表面电极相关的皮肤表面耦合参数变化的更大免疫力，包括位置，水合程度，毛孔和接触压力。最初针对的感官信息包括：抓紧力，对象滑动和手腕。第1阶段的具体目的是开发Optistims，并在肘部截肢者受试者以下1中显示该方法的可行性，并配备了功能性2通道感觉反馈系统。项目叙述：在SBIR II期资金下，正在开发可植入的EMG遥测表。与II期Optistim一起，使用稳定的EMG来源和通过稳定的皮肤神经刺激对感觉的反馈进行闭环控制和感觉的反馈。假肢的功能将得到增强，以改善资深和平民截肢者的生活质量和就业机会。