Ultra-flexible Carbon Nanotube Yarn Electrodes that Integrate with Brain

与大脑集成的超柔性碳纳米管纱线电极

• 批准号: 7391363
• 负责人: DAVID J EDELL
• 金额: $ 19.43万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-10 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391363
• 关键词: Action Potentials; Active Sites; Animals; Area; Athletic; Biocompatible; Blindness; Blood flow; Brain; Brain Part; Carbon; Cephalic; Charge; Chemicals; Chronic; Classification; Communication; Computer software; Contracts; Contralateral; Depth; Electrodes; Electrolytes; Failure; Fostering; Foundations; Head; Histology; Huntington Disease; Hydration status; Implant; Iridium; Knowledge; Laboratories; Length; Link; Mechanics; Medical; Microelectrodes; Movement; Neuraxis; Neurons; Phase; Physiologic pulse; Physiological; Physiology; Plant Roots; Polymers; Prosthesis; Pulse taking; Purpose; Relative (related person); Research; Research Institute; Research Personnel; Residual state; Resistance; Running; Signal Transduction; Site; Sneezing; Source; Spinal cord injury; Structure; Surface; System; Techniques; Technology; Testing; Tissues; Trauma; United States National Institutes of Health; Vibrissae; Work; base; biomaterial compatibility; brain tissue; clinical application; commercialization; comparative; cranium; design; electric impedance; experience; implantation; interest; interfacial; liquid crystal polymer; pressure; programs; prototype; receptor; relating to nervous system; size

DESCRIPTION (provided by applicant): For the past 30 years, there has been extensive interest in developing a communication link between electronically controlled machines and the central nervous system for neuroprosthetics for spinal cord injury, blindness, prosthetic control and many other applications. However, all current applications of chronic neural interface technology are substantially hampered by lack of functional stability in the neural interface, possibly due to the mechanics of the stiff and tethered implants relative to the soft and dynamic brain. There are three dominant sources of mechanical mismatch the interconnects, the interconnect-electrode superstructure, and the electrodes themselves. Mechanical mismatch is a widely recognized shortcoming of the existing technology that this proposed program will largely overcome by creating a chronically implantable, thin, polymer based elastic thread-like interconnect technology that will integrate with the brain surface, and will access neurons of interest through flexible, threadlike electrodes with small but low impedance active sites. The objective of the proposed work is to develop a new cortical neural interface technology that physically and permanently integrates with the pia and cortex and that: 1) maintains long term physiological stability with specific target neurons; 2) are rugged and reliable for many decades; 3) can be readily atraumatically implanted; 3) utilizes advanced, non-fouling, low impedance/high charge capacity capacitive electrode material; and 4) could support economical rapid turn-around prototype runs of investigator generated designs. The feasibility of achieving this objective will be quantitatively assessed over the course of one year by an intense collaborative effort with Foster-Miller, Inc and InnerSea Technology, Inc. Physiological stability will be directly tested using a cortical barrel receptor (whisker) paradigm and automated action potential classification software. In addition, one of the most experienced quantitative histology laboratories in the world, Huntington Medical Research Institute, will provide independent, objective comparative histological analysis of the implanted tissues vs the extensively studied Iridium shaft electrode arrays that they have developed. Following the completion of this proposed Phase I work, the following will have been accomplished: 1) candidate tissue integrative electrode designs will have been identified and verified with mechanical testing (bench); 2) insertion techniques for these will have been developed and evaluated (bench and animals); 3) electrochemical and electrical parameters of the final electrode contacts will have been thoroughly documented (bench and animals); 4) preliminary testing of the physiological stability of the implant system relative to target neurons will have been completed and compared to similar testing in the contralateral cortex using Iridium arrays; and 5) initial objective quantitative assessment of the biocompatibility of the system will be complete. Phase II will begin limited commercialization for neuroprosthetics and other research, confirmation of biocompatibility and bioresistance, and testing of clinical applications in spinal cord injury.

描述（由申请人提供）：在过去的30年里，人们对开发电子控制机器和中枢神经系统之间的通信链路产生了广泛的兴趣，用于脊髓损伤、失明、假肢控制和许多其他应用的神经假肢。然而，慢性神经界面技术的所有当前应用基本上受到神经界面中缺乏功能稳定性的阻碍，这可能是由于刚性和栓系植入物相对于柔软和动态大脑的力学。机械失配有三个主要来源 互连、互连电极超结构和电极本身。机械失配是现有技术的一个被广泛认识到的缺点，该提出的程序将通过创建长期可植入的、薄的、基于聚合物的弹性线状互连技术来在很大程度上克服该缺点，该弹性线状互连技术将与脑表面整合，并且将通过具有小但低阻抗活性位点的柔性线状电极来访问感兴趣的神经元。提出的工作的目标是开发一种新的皮质神经接口技术，该技术在物理上永久地与软脑膜和皮质整合，并且：1）与特定的靶神经元保持长期的生理稳定性; 2）几十年来坚固可靠; 3）可以容易地无损伤植入; 3）利用先进的、无污染的、低阻抗/高电荷容量的电容电极材料;以及4）可以支持研究者生成的设计的经济的快速周转原型运行。实现这一目标的可行性将在一年内通过与Foster-Miller公司和InnerSea技术公司的密切合作进行定量评估。将使用皮质桶受体（须）范例和自动动作电位分类软件直接测试生理稳定性。此外，世界上最有经验的定量组织学实验室之一，亨廷顿医学研究所，将提供植入组织与他们开发的广泛研究的铱轴电极阵列的独立、客观的比较组织学分析。在完成该拟议的第一阶段工作后，将完成以下工作：1）将通过机械测试（台架）识别并验证候选组织集成电极设计; 2）将开发并评价这些电极的插入技术（动物和动物）; 3）最终电极接触的电化学和电气参数将被彻底记录（台架和动物）; 4）将完成植入物系统相对于靶神经元的生理稳定性的初步测试，并与使用铱阵列的对侧皮质中的类似测试进行比较;和5）完成系统生物相容性的初步客观定量评估。第二阶段将开始有限的商业化，用于神经修复和其他研究，确认生物相容性和生物抗性，并测试脊髓损伤的临床应用。