SLOW, LATENT & TEMPERATE VIRUS INFECTIONS

缓慢、潜伏

• 批准号: 6159270
• 负责人: THOMAS J ROWELL
• 金额: $ 66.85万
• 依托单位: UNIVERSITY OF LOUISIANA AT LAFAYETTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-10-31 至 2003-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6159270
• 关键词: Ceboidea; Cercopithecidae; Macaca mulatta; Pan; Primates; animal breeding; animal care; animal colony; communicable disease control; communicable disease diagnosis; communicable disease transmission; disease /disorder model; latent virus infection; neurotropic virus; spongiform encephalopathy; virus infection mechanism

Research efforts concerning the viral study aspect of the contract are focused to determine the safety of the national blood supply in the United States and its military forces serving throughout the world; in the public health safety of animal derived food products; and the development and improvement of sensitive and specific diagnostic tests which will permit the introduction of therapeutic regimens that will either radiate the disease process or block the progression of the various infectious agents known, or suspected, to result in disease that has collectively been identified as Transmissible Spongiform Encephalopathies (TSEs). The contractor provides care, housing, and research support for nonhuman primates assigned to the Laboratory of Central Nervous System Studies, NINDS, in their effort to accomplish these goals. The contractor is responsible for monitoring nonhuman primates that have been, or will be, inoculated via various routes, with tissues known, or suspected to be, infected with one of the TSE agents, recording findings, and performing appropriate procedures to provide the Project Officer with animal samples for evaluation. The objective of the rhesus breeding aspect of the contract is to develop a colony of rhesus macaques capable of providing NINDS scientists with an uninterrupted supply of age-specific, disease-free macaques to continue on-going research projects and initiate new studies.

关于合同病毒研究方面的研究工作重点是确定美国及其在世界各地服役的军队的国家血液供应的安全性;动物源性食品的公共卫生安全性;以及开发和改进敏感和特异性诊断测试，这将允许引入治疗方案，已知或疑似导致疾病的各种感染因子的进展，这些疾病被统称为传染性海绵状脑病（TSE）。 承包商为分配到NINDS中枢神经系统研究实验室的非人灵长类动物提供护理，住房和研究支持，以实现这些目标。承包商负责监测已经或将要通过各种途径接种的非人灵长类动物，其组织已知或疑似感染了一种TSE病原体，记录结果，并执行适当的程序向项目官员提供动物样本进行评价。该合同的恒河猴繁殖方面的目标是开发一个恒河猴群体，能够为NINDS科学家提供不间断的特定年龄、无疾病的猕猴供应，以继续正在进行的研究项目并启动新的研究。