COMPREHENSIVE CENTER FOR INFLAMMATORY DISORDERS

慢性炎症性疾病是当今美国最大的健康问题之一。本申请描述了炎症性疾病综合中心，其使命是支持识别和实施从炎症基本机制研究到预防和治疗口腔和全身炎症性疾病和病症的改进方法的全方位发现。该中心的目标是：1）整合对炎症刺激的细胞反应的基本机制的研究，以更好地了解炎症反应期间发生的细胞活化，运动和功能的基础; 2）将炎症基础研究与动物，患者和人群研究相结合，以更好地了解口腔炎症疾病的细胞和分子基础; 3）确定几种新的和创新的方法来预防，诊断和治疗慢性炎症，并在5年内促进其发展成为治疗口腔和全身炎症性疾病和病症的有效干预措施; 4）利用和扩大正在进行的关于社区教育、筛查、咨询的研究，和相关服务计划，以寻找更好的方法来扩大公共实施的新进展，在预防，诊断和治疗慢性口腔和全身炎症性疾病和障碍; 5）将实验室、临床、人口、教育或社区研究的发现整合到正在进行的中心活动或新的中心计划中;以及6）促进对卫生专业人员和公众进行慢性炎症性疾病和紊乱的病因学、预防、诊断和治疗方面的教育的方案。该中心由基础，临床，流行病学和社区外展和成果研究领域的4个工作组组成，由行政，教育，技术转让和研究支持核心支持。该中心核心旨在：1）促进通过研究发现获得的炎症或炎症性疾病信息的共享，相互解释和整合; 2）提供机制，使发现快速发展为新的研究项目，疗法，干预措施或潜在的市场产品; 3）教育卫生专业人员和公众关于口腔和全身炎症性疾病的健康问题;（4）为每种产品提供必要的行政支持、研究设施、研究服务、协调和科学领导。

Chronic inflammatory disorders are one of the biggest health problems in America today. This application describes the Comprehensive Center for Inflammatory Disorders whose mission is to support the identification and implementation of the full range of discovery from research on the basic mechanisms of inflammation to improved methods in the prevention and treatment of oral and systemic inflammatory diseases and disorders. The goals of the Center are to: 1) integrate studies on the fundamental mechanisms of cellular responses to inflammatory stimuli to better understand the basis of cellular activation, motility, and function that occur during inflammatory responses; 2) integrate basic research studies on inflammation with animal, patient-based and population research to better understand the cellular and molecular basis of oral inflammatory disorders; 3) identify several new and innovative approaches to the prevention, diagnosis, and treatment of chronic inflammation and facilitate their development into effective interventions for the treatment of oral and systemic inflammatory diseases and disorders within 5 years; 4) utilize and expand ongoing research on community education, screening, counseling, and related service programs to find better ways to expand public implementation of new advances in the prevention, diagnosis, and treatment of chronic oral and systemic inflammatory diseases and disorders; 5) integrate discovery from laboratory, clinical, population, education or community-based research into ongoing Center activities or new Center initiatives; and 6) promote programs for the education of health professionals and the public on the etiology, prevention, diagnosis, and treatment of chronic inflammatory diseases and disorders. The Center consists of 4 workgroups in the areas of fundamental, clinical, epidemiologic, and community outreach and outcomes research which are supported by an administrative, educational, technology transfer, and research support core. This Center core is designed to: 1) stimulate sharing, mutual interpretation, and integration of information on inflammation or inflammatory disorders obtained through research discovery; 2) provide mechanisms that allow the rapid development of discovery into new research projects, therapies, interventions, or potentially marketable products; 3) educate health professionals and the public on health issues of oral and systemic inflammatory disorders; and 4) make available to each product essential administrative support, research facilities, research services, coordination, and scientific leadership.