课题基金 / 基金详情

ALCOHOLISM--ADOLESCENT HIGH-RISK TWIN STUDY

ALCOHOLISM--ADOLESCENT HIGH-RISK TWIN STUDY
酗酒——青少年高风险双胞胎研究
批准号:
2000264
负责人:
ANDREW C. HEATH
金额:
$87.31万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-03-01 至 1998-11-30

项目摘要

项目成果

ANDREW C. HEATH的其他基金

相似基金

相关文献

中文摘要
翻译
这份重新修订的五年期提案旨在为一项双胞胎家庭研究寻求资金 青少年酒精使用和滥用,以及相关的行为风险因素, 采用前瞻性队列序贯设计。女性同性群体 对,包括少数民族双胞胎对,他们将年龄为13岁,15岁,17岁和19岁 当他们第一次被研究的时候,已经从国家出生时就被确定了。 记录(N=2350对双胞胎)。 这些家庭目前的地址是 通过简短的电话获得的接合性信息 访谈或邮寄问卷(N= 1785对)。为期四年 在此期间,将与以下儿童的家长进行电话筛选面谈: 双胞胎(N = 1500个家庭)和17岁及以上的双胞胎对(N= 800 pairs)。大约310对夫妇和他们的父母将被随机 被指派进行面对面访谈,并发现190个“高风险”家庭 将根据父母或双胞胎的病史进行面试。 酒精滥用或依赖。年度简短随访电话 将对所有年龄在16-22岁的双胞胎进行访谈, 以及15岁双胞胎的父母;以及一年两次的亲自随访 对父母和双胞胎的采访来自“高风险”和随机的 还将进行对照家庭。我们将评估这对双胞胎 和他们的父母多种措施的酒精使用(数量/频率/ 禁欲,饮酒至醉酒的频率,最大消费量, 与饮酒有关的心理社会问题和其他问题、滥用、依赖); 相关的行为和精神风险因素(行为问题, 行为障碍、对立障碍、多动症、抑郁、焦虑 疾病、其他药物使用史、学业失败);以及 中介和/或调节变量(积极和消极的酒精 期望;价值观;气质和个性测量;家庭 感知环境(Perceived Environment)。多元遗传方法 分析将用于测试有关发展的假设 酒精中毒的遗传风险和环境风险- 因素运作;确定关键的中介和调节变量, 这些发展途径;并探讨联合和相关的 作用(“基因型-环境相关”)和相互作用(“基因型x 环境相互作用”)的遗传和环境风险因素。的 因此,该项目将解决我们在病因学知识方面的一个关键空白 青少年饮酒行为。
英文摘要
This re-revised five-year proposal seeks funding for a twin-family study of adolescent alcohol use and abuse, and related behavioral risk-factors, using a prospective cohort-sequential design. Cohorts of female like-sex pairs, including minority twin pairs, who will be aged 13, 15, 17, and 19 by the time they are first studied, have been ascertained from state birth records (N=2350 twin pairs). Current addresses for the families will be traced, and zygosity information obtained by abbreviated telephone interview or mailed questionnaire (N= 1785 pairs). Over a four-year period, telephone screening interviews will be conducted with parents of the twins (N = 1500 families) and with twin pairs aged 17 and older (N=8O0 pairs). Approximately 310 pairs and their parent(s) will be randomly assigned for in-person interview, and a finder 190 'high-risk' families will be assigned for interview on the basis of parental or twin history of alcohol abuse or dependence. Annual abbreviated follow-up telephone interviews will be conducted with all available twin pairs at ages 16-22, and with the parents of twins aged 15; and biannual in-person follow-up interviews of the parents and twins from the 'high-risk' and random control families will also be conducted. We will assess in both the twins and their parents multiple measures of alcohol use (quantity/frequency/ abstinence, frequency of drinking to intoxication, maximum consumption, drinking-related psychosocial and other problems, abuse, dependence); associated behavioral and psychiatric risk-factors (conduct problems, conduct disorder, oppositionaI disorder, ADHD, depression, anxiety disorders, history of other drug use, academic failure); and postulated mediating and/or moderating variables (positive and negative alcohol expectancies; values; measures of temperament and personality; family environment; perceived environment). Methods of multivariate genetic analysis will be used to test hypotheses concerning the developmental pathways by which genetic risk for alcoholism and environmental risk- factors operate; to identify critical mediating and moderator variables in these developmental pathways; and to explore the joint and correlated action ('genotype-environment correlation') and interaction ('genotype x environment interaction') of genetic and environmental risk-factors. The project will thus address a critical gap in our knowledge of the etiology of adolescent drinking behavior.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Enriching Alcoholism Cohort and Population Studies
  • 批准号:
    8933925
  • 项目类别:
  • 资助金额:
    $62.08万
  • 财政年份:
    2016
  • 负责人:
    ANDREW C. HEATH
  • 依托单位:
Enriching Alcoholism Cohort and Population Studies
  • 批准号:
    9756247
  • 项目类别:
  • 资助金额:
    $56.48万
  • 财政年份:
    2016
  • 负责人:
    ANDREW C. HEATH
  • 依托单位:
Enriching Alcoholism Cohort and Population Studies
  • 批准号:
    9338111
  • 项目类别:
  • 资助金额:
    $58.94万
  • 财政年份:
    2016
  • 负责人:
    ANDREW C. HEATH
  • 依托单位:
NEIGHBORHOOD, FAMILY AND INDIVIDUAL FACTORS IN ADOLESCENT DRINKING
  • 批准号:
    8506595
  • 项目类别:
  • 资助金额:
    $30.2万
  • 财政年份:
    2013
  • 负责人:
    ANDREW C. HEATH
  • 依托单位:
海外基金