NutriPROGRAM: Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways

NutriPROGRAM：通过表观遗传途径代谢健康的早期营养规划

• 批准号: MR/S036520/1
• 负责人: Gemma Sharp
• 金额: $ 34.07万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS036520%2F1
• 关键词: NutriPROGRAM; Early; life; Nutritional; Programming

Pregnancy and infancy are critical periods for nutritional programming of metabolic health. Epigenetic changes seem to have a crucial role in pathways leading from early-life nutrition to metabolic health across the life course. NutriPROGRAM will study key maternal and infant nutrition-related exposures in relation to DNA methylation in mothers and offspring at different ages, and metabolic health across the life course. NutriPROGRAM will specifically focus on cause-and-effect relationships, reversibility of DNA methylation changes by nutrition, lifestyle, physical activity and microbiota, functional consequences of DNA methylation changes and translation into preventive or population-health strategies. Eventually, NutriPROGRAM will develop a sustainable, translational, international collaboration for studies on nutrition and epigenetics and their role in sustaining good health throughout the life course.

孕期和婴儿期是代谢健康营养规划的关键时期。表观遗传变化似乎在整个生命过程中从早期营养到新陈代谢健康的途径中起着至关重要的作用。NutriProGram将研究与不同年龄的母亲和子女的DNA甲基化有关的关键母婴营养暴露，以及整个生命过程中的代谢健康。NutriProGram将特别侧重于因果关系、营养、生活方式、体力活动和微生物区系导致的DNA甲基化变化的可逆性、DNA甲基化变化的功能后果以及转化为预防或人口健康战略。最终，NutriProGram将发展一种可持续的、可转换的国际合作，研究营养和表观遗传学及其在整个生命过程中保持良好健康的作用。

项目成果

The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis.

• DOI: 10.1186/s12978-021-01266-w
• 发表时间: 2021-10-26
• 期刊: Reproductive health
• 影响因子: 3.4
• 作者: Easey KE;Sharp GC
• 通讯作者: Sharp GC

Investigating causality in the association between DNA methylation and prevalent T2D using a bidirectional two-sample Mendelian Randomization

使用双向双样本孟德尔随机化研究 DNA 甲基化与流行的 T2D 之间的因果关系

• DOI: 10.1101/2022.07.20.22277870
• 发表时间: 2022
• 作者: Juvinao-Quintero D

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.

• DOI: 10.1038/s41380-022-01441-w
• 发表时间: 2022-04
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Caramaschi, Doretta;Neumann, Alexander;Cardenas, Andres;Tindula, Gwen;Alemany, Silvia;Zillich, Lea;Pesce, Giancarlo;Lahti, Jari M. T.;Havdahl, Alexandra;Mulder, Rosa;Felix, Janine F.;Tiemeier, Henning;Sirignano, Lea;Frank, Josef;Witt, Stephanie H.;Rietschel, Marcella;Deuschle, Michael;Huen, Karen;Eskenazi, Brenda;Send, Tabea Sarah;Ferrer, Muriel;Gilles, Maria;de Agostini, Maria;Baiz, Nour;Rifas-Shiman, Sheryl L.;Kvist, Tuomas;Czamara, Darina;Tuominen, Samuli T.;Relton, Caroline L.;Rai, Dheeraj;London, Stephanie J.;Raikkonen, Katri;Holland, Nina;Annesi-Maesano, Isabella;Streit, Fabian;Hivert, Marie-France;Oken, Emily;Sunyer, Jordi;Cecil, Charlotte A. M.;Sharp, Gemma
• 通讯作者: Sharp, Gemma

Maternal dietary glycemic index and glycemic load in pregnancy and offspring cord blood DNA methylation

母亲膳食血糖指数和妊娠期血糖负荷及后代脐带血DNA甲基化

• DOI: 10.2337/figshare.19898830
• 发表时间: 2022
• 作者: Felix J

DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality.

DNA 甲基化和 2 型糖尿病：使用孟德尔随机化评估因果关系。

• DOI: 10.1007/s40142-019-00176-5
• 发表时间: 2019
• 期刊: Current genetic medicine reports
• 影响因子: 2.1
• 作者: Juvinao-Quintero DL