PERSISTENCE AND CHANGE IN DRINKING HABITS--PROJECT TWO

饮酒习惯的坚持和改变——项目二

• 批准号: 2732448
• 负责人: ANDREW C. HEATH
• 金额: $ 38.28万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2732448
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; antisocial personality; anxiety disorders; behavioral /social science research tag; behavioral genetics; comorbidity; conduct disorder; disease /disorder proneness /risk; early experience; family genetics; family structure /dynamics; female; gender difference; genotype; health care service utilization; human data; human subject; interview; longitudinal human study; major depression; psychological stressor; psychosis; sex behavior; smoking; substance abuse related disorder; tobacco abuse; twin /multiplet

This revised competing continuation, focused on a cohort of young Australian twin pairs born 1964-1971, surveyed initially by mailed questionnaire in 1990-1992, seeks a further four years support for a study of the role of genetic and social factors, and their covariation and interaction, in the development and natural history of patterns of alcohol use, and of alcohol abuse and dependence, with a particular focus on alcohol problems and alcohol use in women. Telephone interviews will be conducted with some 4500 twins, to assess lifetime history of alcohol dependence and abuse (DSM-IIIR & IV), major depression and anxiety disorders, history of adolescent conduct problems smoking and illicit substance use, traumatic events and other early environmental experiences. Male like-ex and unlike-sex pairs, as well as female like-sex pairs, will be studied, in order to estimate the effects of genotype x gender interaction, and to maximize the precision of estimates of genetic contributions to alcoholism risk in women. Twelve month follow-up interviews will be conducted with pairs where at least one twin screened positive for alcohol dependence (either DSM-IIIR or IV) at stage 1, as well as with a small random sample of 100 male and 100 female unaffected twins. Additional assessments to be obtained at follow-up will include more detailed information about the time course and co-occurrence of problems with alcohol and other comorbid disorders; other substance dependence or abuse, anti-social personality disorder, somatization disorder, and history of oppositional-defiant problems; more detailed assessments of early environment; and measures of health-services utilization, economic and occupational status, and other variables that may be influenced by untreated alcohol problems. These data, together with interview data from an older cohort of twins surveyed by telephone during the current grant cycle (the 1981 cohort: N=6000 twins), and questionnaire data from both cohorts, will be used to test hypotheses about the pathways by which genetic and environmental influences on alcoholism risk arise, and the extent to which such influences vary as a function of gender and birth cohort.

这一修订后的竞争性延续，侧重于一个年轻的队列， 1964-1971年出生的澳大利亚双胞胎，最初通过邮寄调查 1990-1992年的一份调查表，寻求进一步四年的研究支持， 遗传和社会因素的作用，以及它们的协变， 相互作用，在酒精模式的发展和自然历史中， 滥用和依赖，特别侧重于 酒精问题和女性饮酒问题。 电话采访将在 对大约4500对双胞胎进行了研究，以评估一生的饮酒史。 依赖和滥用（DSM-IIIR & IV），重度抑郁和焦虑 青少年行为问题吸烟和非法 物质使用、创伤事件和其他早期环境经历。 男性同性伴侣和异性伴侣，以及女性同性伴侣， 为了估计基因型x性别的影响， 相互作用，并最大限度地提高遗传估计的精度 对女性酗酒风险的贡献。 12个月随访 面试将与至少有一个双胞胎筛选对进行 酒精依赖（DSM-IIIR或IV）在第1阶段阳性， 以及100名男性和100名女性未受影响的小随机样本 双胞胎 随访时获得的其他评估将包括 关于时间进程和共同出现的更多详细信息 酒精和其他共病障碍问题;其他物质 依赖或滥用，反社会人格障碍，躯体化 障碍，以及对立违抗问题的历史;更详细 早期环境评估和保健服务措施 利用率、经济和职业状况以及其他变量， 可能会受到未经治疗的酒精问题的影响。 这些数据一起 通过电话调查， 在当前资助周期内（1981年队列：N=6000对双胞胎），以及 来自两个队列的问卷数据将用于检验假设 关于遗传和环境影响 酒精中毒的风险出现，以及这种影响的程度随着年龄的增长而变化。 性别和出生队列的功能。

项目成果

Smoking, obesity, and hypertension alter the dose-response curve and test sensitivity of carbohydrate-deficient transferrin as a marker of alcohol intake.

吸烟、肥胖和高血压会改变剂量反应曲线，并测试缺乏碳水化合物的转铁蛋白作为酒精摄入标志物的敏感性。

• 发表时间: 1998
• 期刊: Clinical chemistry
• 影响因子: 9.3
• 作者: Whitfield,JB;Fletcher,LM;Murphy,TL;Powell,LW;Halliday,J;Heath,AC;Martin,NG
• 通讯作者: Martin,NG

Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression.

• DOI: 10.1001/archgenpsychiatry.2011.1385
• 发表时间: 2012-03
• 期刊: ARCHIVES OF GENERAL PSYCHIATRY
• 作者: Sartor, Carolyn E.;Grant, Julia D.;Lynskey, Michael T.;McCutcheon, Vivia V.;Waldron, Mary;Statham, Dixie J.;Bucholz, Kathleen K.;Madden, Pamela A. F.;Heath, Andrew C.;Martin, Nicholas G.;Nelson, Elliot C.
• 通讯作者: Nelson, Elliot C.

Spousal concordance for alcohol dependence: Evidence for assortative mating or spousal interaction effects?

• DOI: 10.1111/j.1530-0277.2007.00356.x
• 发表时间: 2007-05-01
• 期刊: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
• 影响因子: 3.2
• 作者: Grant, Julia D.;Heath, Andrew C.;Martin, Nicholas G.
• 通讯作者: Martin, Nicholas G.

Genetic covariation between serum gamma-glutamyltransferase activity and cardiovascular risk factors.

血清γ-谷氨酰转移酶活性与心血管危险因素之间的遗传协变。

• 发表时间: 2002
• 期刊: Clinical chemistry
• 影响因子: 9.3
• 作者: Whitfield,JohnB;Zhu,Gu;Nestler,JohnE;Heath,AndrewC;Martin,NicholasG
• 通讯作者: Martin,NicholasG

The role of harsh discipline in explaining sex differences in conduct disorder: a study of opposite-sex twin pairs.

严厉管教在解释品行障碍中性别差异中的作用：对异性双胞胎的研究。

• DOI: 10.1007/s10802-009-9309-1
• 发表时间: 2009
• 期刊: Journal of abnormal child psychology
• 影响因子: 3.6
• 作者: Meier,MadelineH;Slutske,WendyS;Heath,AndrewC;Martin,NicholasG
• 通讯作者: Martin,NicholasG