LOng-Term anatomical fluid dynamics for new Univentricular heartS palliation (LOTUS)

新单心室心脏姑息治疗的长期解剖流体动力学 (LOTUS)

• 批准号: MR/T017988/1
• 负责人: Paul Houston
• 金额: $ 41.08万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT017988%2F1
• 关键词: LOng; Term; anatomical; fluid; dynamics

Children with functionally univentricular hearts (UVH) have poor life prognosis, despite surgical treatment. This project aims to build an open-source combined Artificial Intelligence and Computational Fluid Dynamics (CFD) tool to determine 'optimal' designs for the Fontan procedure to be used by surgeons, to enhance patient life expectancy (currently 20-30 years).Detailed imaging from UVH patients will be provided by USM to produce 3D geometries on which UK numerical models can be applied. USM currently treats 40-50 new UVH patients/year and 150 in follow-up, therefore they have a large databank covering a wide range of anatomical morphologies changing with patient growth and various palliative stages. This databank enables the construction of a novel mathematical model of how morphology/flow in later life depends on surgical procedure, with the prediction of the 'optimal' surgical design minimizing the negative impact of the Fontan circulation. Combining high-fidelity curvilinear discretization, multiscale modelling, and machine learning, the CFD tool will reliably inform on long-term impact of surgical procedures, including a novel physiological Fontan procedure by the UK team.Expected outcomes. 1. Study of the long-term prognosis of subjects with complex congenital heart defects, specifically following all patients with UVH. 2. Consolidate partnership between Malaysia and UK teams, provide training to USM personnel introducing CFD tools for surgery optimisation. 3. Develop a patient-specific open-source computational tool to optimize surgical procedures in children with functionally UVH, for better long-term quality of life. 4. Combine artificial intelligence techniques with efficient and reliable multiscale CFD modelling based on recent polyhedral discretisations to predict long-term outcome of surgery. 5. We envisage that the project's tool will provide a new insight on the reason for the failure of UVH palliation. 6. The tool will also permit the validation of new Fontan procedures based on more physiological types of surgical connections, such as the one recently proposed and evaluated with CFD studies by the UK team.

功能性单心室心脏（UVH）的儿童，即使手术治疗，预后也很差。该项目旨在构建一个开源的人工智能和计算流体动力学（CFD）工具，以确定外科医生使用的Fontan程序的“最佳”设计，以提高患者的预期寿命（目前为20-30岁）。USM将提供UVH患者的详细成像，以产生3D几何形状，并在其上应用UK数值模型。USM目前每年治疗40-50名新的UVH患者，150名患者在随访中，因此他们有一个大型数据库，涵盖了随着患者生长和各种姑息阶段而变化的各种解剖形态。该数据库能够构建一种新的数学模型，该模型描述了晚年的形态/血流如何取决于外科手术，预测“最佳”手术设计，最大限度地减少Fontan循环的负面影响。结合高保真曲线离散化、多尺度建模和机器学习，CFD工具将可靠地为外科手术的长期影响提供信息，包括英国团队的新型生理Fontan手术。预期结果。1.研究复杂先天性心脏病受试者的长期预后，特别是所有UVH患者。2.巩固马来西亚和英国团队之间的伙伴关系，为USM人员提供培训，介绍CFD工具用于手术优化。3.开发一种患者特定的开源计算工具，以优化功能性UVH儿童的手术程序，以提高长期生活质量。4.将联合收割机人工智能技术与基于最新多面体离散化的高效可靠的多尺度CFD建模相结合，以预测手术的长期结果。5.我们设想，该项目的工具将提供一个新的见解的原因UVH姑息治疗失败。6.该工具还将允许基于更多生理类型的手术连接来验证新的Fontan程序，例如最近由英国团队提出并通过CFD研究进行评估的程序。

项目成果

A Posteriori Error Analysis for Implicit-Explicit hp-Discontinuous Galerkin Timestepping Methods for Semilinear Parabolic Problems

半线性抛物型问题隐式-显式hp-不连续伽辽金时间步长方法的后验误差分析

• DOI: 10.1007/s10915-020-01130-2
• 发表时间: 2020
• 期刊: Journal of Scientific Computing
• 影响因子: 2.5
• 作者: Cangiani A

h p -adaptive discontinuous Galerkin methods for non-stationary convection-diffusion problems

非平稳对流扩散问题的 h p 自适应间断伽辽金方法

• DOI: 10.1016/j.camwa.2019.04.002
• 发表时间: 2019
• 期刊: Computers & Mathematics with Applications
• 影响因子: 2.9
• 作者: Cangiani A

Convergence of an adaptive discontinuous Galerkin method for elliptic interface problems

椭圆界面问题的自适应间断伽辽金法的收敛性

• DOI: 10.1016/j.cam.2019.112397
• 发表时间: 2020
• 期刊: Journal of Computational and Applied Mathematics
• 影响因子: 2.4
• 作者: Cangiani A

$hp$-Version discontinuous Galerkin methods on essentially arbitrarily-shaped elements

$hp$ - 基本上任意形状的元素上的不连续伽辽金方法的版本

• DOI: 10.48550/arxiv.1906.01715
• 发表时间: 2019
• 作者: Cangiani A

Adaptive non-hierarchical Galerkin methods for parabolic problems with application to moving mesh and virtual element methods

• DOI: 10.1142/s0218202521500172
• 发表时间: 2020-05
• 期刊: ArXiv
• 作者: A. Cangiani;E. Georgoulis;Oliver J. Sutton