ENVIRONMENTAL EFFECTS ON FERTILITY

环境对生育力的影响

• 批准号: 6106669
• 负责人: DONNA D. BAIRD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106669
• 关键词: clinical research; diethylstilbestrol; embryo /fetus toxicology; environmental toxicology; epidemiology; estrogens; fertility; hormone metabolism; human subject; menstrual cycle; mercury poisoning; nitrous oxide; occupational hazard; ovary disorder; ovulation detection /prediction; ovulation time; progesterone; questionnaires

Summary of Work: The primary purpose of the project on fertility is to develop methods for identifying reproductive hazards. Ultimately, we are working toward developing methods for studying reproductive hazards in small populations so that localized exposures can be evaluated. First, we have developed questionnaire methods for measuring fertility using data on time to pregnancy, the number of noncontracepting menstrual cycles required to conceive. This measure can be the focus of epidemiologic studies of fertility or can be integrated into epidemiologic studies of other diseases such as breast cancer. Data from female dentists is being examined to study the relationship between mercury and nitrous oxide exposures and female reproduction. Data on fertility are also being collected in the Agricultural Health Study. These data will be available for an analysis of pesticide related effects and fertility in the fall of 1997. Our second approach focusses on developing biological markers of impaired ovarian function. We have begun by examining urinary metabolites of estrogen and progesterone. These have been measured in daily urine specimens from over 700 menstrual cycles from about 200 women. First, we developed a method for detecting day of ovulation using these urinary hormone data. Our ability to detect ovulation using this method was very good. Now we are developing methods for characterizing follicular development, luteal function, and hormonal factors associated with conception and pregnancy loss.

工作总结： 关于生育率的项目是制定方法， 生殖危害最终，我们将致力于 发展研究小型哺乳动物生殖危害的方法， 这样就可以对局部暴露进行评估。一是 已经开发了测量生育率的问卷方法， 关于怀孕时间、未避孕人数、 怀孕所需的月经周期。这种方法可以是 生育力流行病学研究的焦点或可以整合到 其他疾病如乳腺癌的流行病学研究。数据 正在研究女性牙医的 汞和一氧化二氮暴露与女性 生殖关于生育率的数据也正在收集， 农业健康研究。这些数据将提供给 1997年秋季与农药有关的影响和生育力分析。 我们的第二种方法侧重于开发生物标志物， 卵巢功能受损我们首先检查了 雌激素和孕激素的代谢物。这些已经 在超过700个月经周期的日常尿液样本中测量 大约200名女性。首先，我们开发了一种方法， 用这些尿激素数据来计算排卵日。的能力 用这种方法检测排卵是很好的。现在我们正在 用于表征卵泡发育、黄体发育的方法 功能，以及与受孕相关的激素因素， 流产