Environmental Effects On Fertility

环境对生育力的影响

• 批准号: 9143428
• 负责人: DONNA D. BAIRD
• 金额: $ 13.31万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9143428
• 关键词: Agreement; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinical; Conceptus; Data; Data Analyses; Development; Enrollment; Epidemiologic Studies; Fertility; Fertility Study; Goals; Hemorrhage; Hormones; Human Chorionic Gonadotropin; Interview; Manuscripts; Measurement; Medical; Menstrual cycle; Methods; Monitor; Outcome; Ovarian; Pain; Participant; Patient Self-Report; Pilot Projects; Plasma; Pregnancy; Pregnancy Outcome; Pregnancy Tests; Pregnancy loss; Protocols documentation; Publications; Questionnaires; Reporting; Reproduction; Reproductive Process; Research; Resources; Sampling; Self-Administered; Specimen; Spontaneous abortion; Steroids; Time; Urine; Validity of Self Report; Vitamin D; Woman; Work; birth control; design; phthalates; prospective; reproductive hormone; stability testing; urinary

Data from the Early Pregnancy Study (EPS) (A.Wilcox, PI) provide a resource for ongoing research into reproductive hormones, fertility, & early pregnancy. During field work for this study in 1982-1985, women enrolled at the time they stopped using birth control in order to conceive. We followed them through their 8th week of pregnancy. They collected daily first morning urine specimens and these were analyzed for human chorionic gonadotropin and steroid metabolites. Women with known fertility problems were excluded, so the sample represents normal unassisted reproduction. We conducted a pilot study to test the stability of hormones in urines stored from the Early Pregnancy Study. Pilot work supported the validity of BPA and phthalate measurements in the EPS urines after long-term storage, so we have designed a study to look at the association of those exposures with fertility and pregnancy outcomes in EPS. We designed a sample selection protocol (pool of 3 separate daily specimens) to the assess levels in each participant menstrual cycle and each clinical pregnancy. These have been analyzed at CDC. In preliminary analysis of the data, there is no evidence of any associations between BPA or phthalates and early pregnancy loss or time to pregnancy. A comprehensive analysis has been completed and accepted for publication in EHP. Epidemiologic study of menstrual characteristics, fertility, and miscarriage relies on self-report because these outcomes are not systematically monitored by medical care protocols. Therefore, study validity depends upon the accuracy of self-report for these outcomes. We have evaluated the validity of self-reported cycle characteristics by comparing interview data to prospective daily recording of menstrual bleeding and pain. In another methodologic project, we are using available data to determine how well women can report the timing of their positive pregnancy test. Bias arises in spontaneous abortion & time-to-pregnancy studies when comparing exposed and unexposed groups that differ in timing of pregnancy testing. Those who tend to have delayed pregnancy testing will recognize fewer spontaneous abortions, and they will have longer times to pregnancy. In another analysis we are comparing self-reported retrospective data on time to pregnancy with prospectively-collected data (documented for participants in the Early Pregnancy Study during their participation). Participants were traced and sent a self-administered questionnaire to collect their retrospective self-reports. A manuscript has been submitted. Even after 25-30 years there was good agreement of self-report with the prospectively observed time to pregnancy. In recent work with vitamin D we have found that low vitamin D, as assessed by 25(OH)D in plasma from women 35-49 is associated with lower ovarian reserve, as assessed by urinary FSH from specimens collected outside of the midcycle surge in FSH. Low vitamin D was also found to be associated with irregular menstrual cycles.

早期妊娠研究（EPS）的数据（a . wilcox， PI）为正在进行的生殖激素、生育能力和早期妊娠的研究提供了资源。在1982-1985年的实地研究中，参与研究的女性都是在停止使用避孕措施以怀孕的时候。我们跟踪她们到怀孕的第8周。他们收集了每天早晨的尿液样本，并对这些样本进行了人类绒毛膜促性腺激素和类固醇代谢物的分析。已知有生育问题的妇女被排除在外，因此样本代表正常的无辅助生殖。我们进行了一项初步研究，以测试从早期妊娠研究中储存的尿液中激素的稳定性。