Environmental Effects On Fertility

环境对生育力的影响

• 批准号: 6837566
• 负责人: DONNA D. BAIRD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6837566
• 关键词: caffeine; clinical research; contraceptives; corpus luteum; embryo implantation; environmental contamination; environmental exposure; estrogens; fertility; health surveys; hormone metabolism; human subject; interview; luteinizing hormone; mathematical model; menstrual cycle; obesity; ovary disorder; ovulation detection /prediction; ovulation time; personal log /diary; pregnancy loss; progesterone; questionnaires; smoking; urinalysis

Adverse effects on reproductive capacity can occur at every phase of the reproductive process from prenatal development, puberty, to time when conception is occurring and the pregnancy is developing. This research project includes several aspects of the reproductive process, but mostly focuses on factors affecting the ability to conceive and maintain the pregnancy through its first few weeks. The complex biological processes involved include gamete development and maturation, sperm transport through the female reproductive tract, fertilization, early development of the conceptus, implantation, and maintenance of the developing embryo/trophoblast. We have developed methods to estimate environmental effects on fecundability, defined as the per menstrual cycle probability of conceiving, and we have followed women with daily urinary hormone measurements through their pregnancy attempts and early pregnancies. The biological underpinnings of fertility can also influence general health, and we have considered the health effects of female hormones within the framework of this project. The general aims of the project are to 1) refine methods for studying fertility, 2) to provide basic data documenting normal fertility and early development of the conceptus, 3) to investigate the impact of exposures that perturb normal reproductive processes.

对生殖能力的不利影响可能发生在生殖过程的每一个阶段，从产前发育、青春期到受孕和怀孕过程中。该研究项目包括生殖过程的几个方面，但主要集中在影响怀孕能力和维持怀孕前几周的因素。所涉及的复杂生物学过程包括配子发育和成熟、精子通过雌性生殖道的运输、受精、孕体的早期发育、植入和发育中的胚胎/滋养层的维持。我们已经开发出方法来估计环境对生育能力的影响，定义为每个月经周期的怀孕概率，我们已经跟踪了女性在怀孕尝试和早孕期间的每日尿激素测量。生育的生物学基础也会影响一般健康，我们在本项目的框架内考虑了女性激素对健康的影响。 该项目的总体目标是：（1）改进研究生育力的方法，（2）提供记录正常生育力和孕体早期发育的基本数据，（3）调查干扰正常生殖过程的照射的影响。