Statistical Analysis of Genetic Analysis Workshop 11 Data

遗传分析研讨会11数据的统计分析

• 批准号: 6109059
• 负责人: Joan Ellen Bailey-Wilson
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6109059
• 关键词: alcoholism /alcohol abuse; amine oxidase (flavin); computer simulation; family genetics; genetic susceptibility; human data; linkage mapping; statistics /biometry; tobacco abuse

This project involved analysis of two datasets from the Genetic Analysis Workshop 11. A set of data from the COGA study of alcoholism was analyzed using linkage and association techniques, finding evidence for possible linkage on chromosome 12 of a locus influencing monoamine oxidase activity and showing that this locus may be more important in smokers than in non- smokers. Another set of data was for an extremely complex computer simulated trait. Several methods of analysis both ignoring and attempting to adjust for an environmental risk factor were compared. It was found that major increases in power in sib-pair linkage analyses can be obtained by analyzing only persons exposed to the risk factor, if the environmental risk factor has a fairly large effect on penetrance. Two manuscripts have been submitted for publication.

该项目涉及分析两个数据集 基因分析工作坊11.来自COGA的一组数据 酒精中毒的研究分析使用连接和关联 技术，寻找染色体上可能存在连锁的证据 12个影响单胺氧化酶活性的位点， 这个基因座在吸烟者中可能比在非吸烟者中更重要， 吸烟者。另一组数据是一个非常复杂的 计算机模拟的特性几种分析方法都忽略了 并试图调整环境风险因素， 比较了结果发现，主要增加功率在同胞对 通过仅分析暴露人员， 如果环境风险因素具有相当大的 对睡眠的影响已提交两份手稿， 出版物