Auditory Cognition in Alzheimer's Disease

阿尔茨海默病的听觉认知

• 批准号: MR/V006568/1
• 负责人: Meher Lad
• 金额: $ 31.44万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV006568%2F1
• 关键词: Auditory; Cognition; Alzheimer; Disease

To create tests to predict and diagnose dementia, it is important to understand how problems with memory and thinking develop. Hearing loss may be involved in how dementia develops, and testing hearing could help to predict and diagnose the condition. I want to find out whether the effects of hearing loss on memory and thinking are due to problems with people's ability to hold sounds in mind. This is called auditory working memory (AWM for short). For example, AWM is very important when we are trying to have a conversation in a noisy room and identify the speaker's words correctly. Problems with AWM can mean that people have poor hearing, even though they have good results on conventional hearing tests.I will examine the brain network for AWM by scanning the brains of people with and without Alzheimer's disease, to find out if there are differences that can explain why problems with memory and thinking occur. I will look at:1. Whether people with Alzheimer's disease have problems with AWM2. Whether problems with AWM are linked to changes in a part of the brain called the hippocampus, which is crucial for memory, and is also affected early in Alzheimer's disease.This project will provide the basis for further large-scaled studies where people's AWM performance is assessed over time to show how this test can be used to identify people with Alzheimer's disease early in the disease course.

要创建预测和诊断痴呆症的测试，重要的是了解记忆和思维问题是如何发展的。听力损失可能与痴呆症的发展有关，听力测试可以帮助预测和诊断这种情况。我想知道听力损失对记忆和思维的影响是否是由于人们记住声音的能力出现了问题。这被称为听觉工作记忆(AWM)。例如，当我们试图在嘈杂的房间里进行对话并正确识别说话人的话时，AWM是非常重要的。AWM的问题可能意味着人们的听力很差，即使他们在传统的听力测试中取得了良好的结果。我将通过扫描患有阿尔茨海默病和没有阿尔茨海默病的人的大脑来检查AWM的大脑网络，以找出是否有差异可以解释为什么记忆和思维会出现问题。我会看看：1。阿尔茨海默病患者是否有AWM2问题。AWM的问题是否与大脑的一部分海马体的变化有关，海马体对记忆至关重要，也会在阿尔茨海默病的早期受到影响。这个项目将为进一步的大规模研究提供基础，在这些研究中，随着时间的推移，评估人们的AWM表现，以展示这种测试如何在疾病病程的早期用来识别阿尔茨海默病患者。

项目成果

The Motor Basis for Misophonia.

• DOI: 10.1523/jneurosci.0261-21.2021
• 发表时间: 2021-06-30
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Kumar S;Dheerendra P;Erfanian M;Benzaquén E;Sedley W;Gander PE;Lad M;Bamiou DE;Griffiths TD
• 通讯作者: Griffiths TD

A specific relationship between musical sophistication and auditory working memory

音乐复杂度和听觉工作记忆之间的特定关系

• DOI: 10.1101/2021.07.08.451659
• 发表时间: 2021
• 作者: Lad M

Dementia and disorders of cognition

痴呆症和认知障碍

• DOI: 10.1016/j.mpmed.2023.05.002
• 发表时间: 2023
• 期刊: Medicine
• 影响因子: 1.6
• 作者: Lad M

Sensory Loss and Risk of Dementia

• DOI: 10.1177/10738584221126090
• 发表时间: 2022-09
• 期刊: The Neuroscientist
• 作者: M. Lad;W. Sedley;T. Griffiths

The hearing hippocampus.

• DOI: 10.1016/j.pneurobio.2022.102326
• 发表时间: 2022-11
• 期刊: PROGRESS IN NEUROBIOLOGY
• 影响因子: 6.7
• 作者: Billig, Alexander J.;Lad, Meher;Sedley, William;Griffiths, Timothy D.
• 通讯作者: Griffiths, Timothy D.