Instrumentation for Spectral Karyotyping
Instrumentation for Spectral Karyotyping
批准号:
6112724
负责人:
Paul D Smith
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
光谱核型分析是一种不断发展的细胞遗传学
识别染色体重排的技术,例如
癌细胞系中观察到的缺失、倒位和易位。一个
商业乐器作为改进的 Sagnac 运行
安装在落射照明显微镜上的干涉仪
捕获用于绘画的探针的光谱特征
染色体。落射照明端口和荧光立方体
显微镜的组件已被修改,以允许单个
波长激发,导致大于一个数量级
信噪比的幅度改善
荧光信号和总体背景信号的减少。
这些改进将允许分辨率更小的染色体
条带异常及其相关性的识别
疾病。
英文摘要
Spectral karyotyping is an evolving cytogenetic
technology to identify chromosomal rearrangements such as
deletions, inversions, and translocations seen in cancer cell lines. A
commercial instrument operates as a modified Sagnac
interferometer installed on an epi-illumination microscope to
capture the spectral signature of probes used to paint
chromosomes. The epi-illumination port and the fluorescent cube
assembly of the microscope have been modified to permit single
wavelength excitation, resulting in greater than an order of
magnitude improvement in the signal to noise ratio of the
fluorescent signals and a reduction in the overall background signal.
These improvements will permit resolution of smaller chromosome
band abnormalities and identification of their correlation with
disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Seventh Biennial Wisconsin Health Literacy Summit: A Critical Link in Patient Engagement
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批准号:9318767
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项目类别:
-
资助金额:$3.5万
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财政年份:2017
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负责人:Paul D Smith
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依托单位:
2013 Wisconsin Health Literacy Summit: Changing Systems, Changing Lives
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批准号:8461368
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项目类别:
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资助金额:$4.99万
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财政年份:2012
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负责人:Paul D Smith
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依托单位:
2011 Wisconsin Health Literacy Summit
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批准号:8096005
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项目类别:
-
资助金额:$5.0万
-
财政年份:2011
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负责人:Paul D Smith
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依托单位:
STRUCTURE STUDIES OF MIMIVIRUS CAPPING ENZYMES
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批准号:7726241
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项目类别:
-
资助金额:$0.85万
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财政年份:2008
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负责人:Paul D Smith
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依托单位:
STRUCTURE STUDIES OF MIMIVIRUS CAPPING ENZYMES
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批准号:7602308
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项目类别:
-
资助金额:$0.67万
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财政年份:2007
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负责人:Paul D Smith
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依托单位:
Atomic Force Microscopy Instrumentation and Applications
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批准号:6837020
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Propagation of Light in Tissue and Imaging
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批准号:6684962
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Microfabrication for Biomedical Research
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批准号:6836995
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Propagation of Light in Tissue and Imaging
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批准号:6836950
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Development of Optical Systems for Retina Evaluation
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批准号:7319103
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Propagation of Light in Tissue and Imaging
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批准号:7146055
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Microfabrication for Biomedical Research
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批准号:7146058
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Instrumentation / Bioengineering Development /Applicatio
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批准号:7012528
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Miniature In-line Microfluidic LIF Detector
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批准号:7146085
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
INSTRUMENTATION FOR SPECTRAL KARYOTYPING
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批准号:6290706
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Instrumentation and Bioengineering Development and Application
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批准号:6228081
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Calorimetry Instrumentation and Biophysics
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批准号:6837019
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
OPTICAL EVALUATION OF ORAL TISSUES WITH LEUKOPLKIA
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批准号:6413436
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Instrumentation For Spectral Karyotyping
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批准号:6548625
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
Instrumentation And Bioengineering Development
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批准号:6548656
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Paul D Smith
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依托单位:
海外基金