COCAINE EFFECTS ON CEREBRAL BLOOD FLOW--OXYGEN 15 PET

可卡因对脑血流的影响--OXYGEN 15 PET

• 批准号: 6114277
• 负责人: GODFREY D PEARLSON
• 金额: $ 2.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114277
• 关键词: blood flow measurement; clinical research; cocaine; dopamine antagonists; human subject; male; neuropharmacology; oxygen; positron emission tomography; psychopharmacology; radionuclides; radiotracer

Cocaine is a commonly abused euphoriant with strong reinforcing effects. Animal data have shown that the reinforcing properties are related to cocaine's activity on the dopamine system. We designed a Positron Emission Tomography study to investigate cocaine's activity in humans on regional cerebral flow in dopaminergically innervated and comparison regions. Four subjects were injected with 015water 30 to 180 seconds after cocaine injection. All subjects reported subjective euphoriant effects on Visual Analog Scales. Global cerebral blood flow was reduced 32+8% in all subjects. Maximal decreases were seen 60 seconds after cocaine injection. We demonstrated that doses of cocaine similar to typical "street doses" reduce global blood flow acutely. Further analyses, once adequate subject numbers are available, will yield data on local changes.

可卡因是一种常被滥用的兴奋剂，具有很强的强化作用。