COCAINE EFFECTS ON CEREBRAL BLOOD FLOW--OXYGEN 15 PET

可卡因对脑血流的影响--OXYGEN 15 PET

• 批准号: 6218221
• 负责人: GODFREY D PEARLSON
• 金额: $ 0.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6218221
• 关键词: blood flow measurement; clinical research; cocaine; dopamine antagonists; dopamine receptor; human subject; male; neuropharmacology; oxygen; pharmacokinetics; psychopharmacology; radiotracer

We have run two subjects in the past 12-month period. The co-investigator on the grant, Dr. Thomas Schlaepfer, has temporarily returned to Switzerland in order to oversee the running of his own Neuroimaging Laboratory at the University of Bern. Pilot results so far are encouraging, and show activation in expected regions of basal ganglia, frontal lobe, and mesial temporal areas, which we hypothesized would be involved in cocaine's cerebral activity. Dr. Schlaepfer is returning to the United States for a visiting academic appointment in the 1999-2000 period and more subjects will be run in the study during this time.

在过去的12个月里，我们已经运行了两个主题。 该基金的合作研究者托马斯·施莱普费尔博士暂时返回瑞士，以监督他在伯尔尼大学的神经影像实验室的运行。 到目前为止，初步结果令人鼓舞，并显示在基底神经节，额叶和内侧颞区的预期区域激活，我们假设这将涉及可卡因的大脑活动。 Schlaepfer博士将在1999-2000年期间返回美国进行访问学术任命，在此期间将有更多的受试者参加研究。