INTERACTION OF DRUGS W/ DNA TRIPLEXES

我们一直在研究几种配体与 短，DNA三链体，以检查序列，阳离子和 基地改造 已经研究了几种类型的三链体， 例如具有由嘧啶或嘌呤组成的第三链的那些， 鸟嘌呤和胸腺嘧啶的混合物。 虽然大多数的嵌入者， 研究表明，它们可以与这些三链体结合， 到双胞胎。 MidasPlus已被证明在可视化方面具有很大的实用性 三链体之间的相互作用类型

We have been studying the interaction of several ligands with short, DNA triplexes to examine the effect of sequence, cations and base modifications. Several types of triplexes have been examined, such as those with third strands composed of pyrimidines or purines or a mixture of guanine and thymine. While most of the intercalators we have studied can bind to these triplexes, they tend to prefer binding to the duplexes. MidasPlus has proved of great utility in visualizing the types of interactions that can occur with triplexes.