INTERACTION OF DRUGS W/ DNA TRIPLEXES

我们一直在研究几种配体与 短DNA三联体，用于检测序列、阳离子和 碱基修改。已经研究了几种类型的三联体， 例如具有由嘧啶或嘌呤组成的第三链或 鸟嘌呤和胸腺嘧啶的混合物。虽然我们大多数的嵌入者 已经研究过可以与这些三联体结合的人，往往倾向于结合 送到复式公寓。MidasPlus已被证明在可视化方面非常有用 可以与三联体发生的交互类型。

We have been studying the interaction of several ligands with short, DNA triplexes to examine the effect of sequence, cations and base modifications. Several types of triplexes have been examined, such as those with third strands composed of pyrimidines or purines or a mixture of guanine and thymine. While most of the intercalators we have studied can bind to these triplexes, they tend to prefer binding to the duplexes. MidasPlus has proved of great utility in visualizing the types of interactions that can occur with triplexes.