INTERACTION OF DRUGS W/ DNA TRIPLEXES

药物与 DNA 三链体的相互作用

• 批准号: 6280267
• 负责人: YUJIAN HE
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280267
• 关键词: biological products; biomedical resource

We are studying the interaction of several ligands with short, DNA triplexes to examine the effect of sequence, cations and base modifications. Several types of triplexes have been examined, such as thos e with third strands composed of pyrimidines or purines or a mixture of guanine and thymine. While most of the intercalators we studied can bind to these triplexes, they tend to prefer binding to the duplexes. MidasPlus is of great utility in visualizing the types of interactions that can occur with triplexes.

我们正在研究几种配体与短DNA的相互作用