INTERACTION OF DRUGS W/ DNA TRIPLEXES

药物与 DNA 三链体的相互作用

• 批准号: 6280187
• 负责人: YUJIAN HE
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280187
• 关键词: biological products; biomedical resource

We have been studying the interaction of several ligands with short, DNA triplexes to examine the effect of sequence, cations and base modifications. Several types of triplexes have been examined, such as those with third strands composed of pyrimidines or purines or a mixture of guanine and thymine. While most of the intercalators we have studied can bind to these triplexes, they tend to prefer binding to the duplexes. MidasPlus has proved of great utility in visualizing the types of interactions that can occur with triplexes.

我们一直在研究几种配体与 简短的 DNA 三链体，用于检查序列、阳离子和 基础修改。 已经检查了几种类型的三联体， 例如具有由嘧啶或嘌呤组成的第三链的那些，或 鸟嘌呤和胸腺嘧啶的混合物。 虽然大多数嵌入剂我们 已研究可以结合这些三链体，他们倾向于更喜欢结合 到复式公寓。 MidasPlus 已被证明在可视化方面非常有用 三联体可能发生的相互作用类型。