FLOW ESTIMATION FROM TRACERS UNDERGOING TRANSCAPILLARY EXCHANGE

对成功开发多毛细管的后续行动 核磁共振法估计局部心肌血流的模型 血管内造影剂，我们将开发技术 使用更大的类别估计局部心肌血流量 标记物，即从血液中逸出的标记物 跨毛细管通道。第一阶段需要记录的数据在 输入函数的形式；在后面的阶段中，我们将尝试 估计输入函数形式，以便分析将适合 对于像大脑这样的器官，输入不容易被记录下来 直接去吧。方法的发展包括灵敏度分析， 评估适用范围、对噪声的敏感性和 对数据采集率的依赖。这个项目是直接的 D.II，E.1的继任者。

Following up on the successful development of a multicapillary model for the estimation of regional myocardial flows by NMR using an intravascular contrast agent, we will develop the techniques for estimating regional myocardial blood flows using a larger class of markers, namely those which escape from the blood during transcapillary passage. The first stage requires the recorded data on the form of the input function; in later stages we will try to estimate the input function form so that the analysis will be suitable for organs like the brain where the input is not readily recorded directly. The method development includes sensitivity analysis, assessment of ranges of applicability, susceptibility to noise, and dependence upon data acquisition rates. this project is the direct successor to D.II.E.1.