WHOLE BODY DISTRIBUTION & PHARMACOKINETIC MODELS

仿真资源的一个中心目标是提供 了解血液组织交换动力学的工具。 的 特别令人感兴趣的是流出指示剂稀释技术、残留物 应用于正电子发射断层扫描（PET）的技术、磁 磁共振成像（MRI）和X射线计算机断层扫描（CT）， 载体介导的转运和受体动力学的表征， 和高分辨率药代动力学。 在一些实验中， 这些设置可以在开放（即，非再循环） 系统中，许多实验都是在完整的受试者中进行的， 分析需要使用全身再循环模型。 的 本项目的目标是开发一套示踪剂模型 运输和交换，是足够现实，准确地 考虑到观察到的解剖和生理数据， 广泛的未代谢和代谢底物、离子， 荷尔蒙在整个身体。 这些模型将以一种 计算速度足够快， 在工作站上拟合数据和参数估计，而不是 超级计算机 它们也将被建造，以便它们能够 简化为房室形式，因此可以进行比较 在生理上真实的分布式模型和传统的 房室分析

A central target for the Simulation Resource is the provision of tools for understanding the kinetics of blood-tissue exchange. Of particular interest are outflow indicator dilution techniques, residue techniques applied to positron emission tomography (PET), magnetic resonance imaging (MRI), & X-ray computed tomography (CT), the characterization of carrier-mediated transport and receptor kinetics, and high resolution pharmacokinetics. While in some experimental settings these can be examined in open (i.e., non-recirculating) systems, many experiments are performed in intact subjects, and their analysis requires the use of whole-body, recirculating models. The goal of this project is to develop a set of models for tracer transport and exchange that are sufficiently realistic to accurately account for observed anatomic and physiologic data for the behavior of a wide range of unmetabolized and metabolized substrates, ions, and hormones in the whole body. These models will be coded in a manner that the computation is rapid enough that they can be used for model fitting to data and parameter estimation on workstations rather than supercomputers. They will also be constructed so that they can be reduced to compartmental forms and can, thus, allow comparisons between physiologically realistic distributed models and traditional compartmental analysis.