WHOLE BODY DISTRIBUTION & PHARMACOKINETIC MODELS

全身分布

• 批准号: 6308561
• 负责人: JAMES B BASSINGTHWAIGHTE
• 金额: $ 2.35万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308561
• 关键词: Mammalia; bioengineering /biomedical engineering; biomedical resource; cardiovascular system; human tissue; technology /technique

A central target for the Simulation Resource is the provision of tools for understanding the kinetics of blood-tissue exchange. Of particular interest are outflow indicator dilution techniques, residue techniques applied to positron emission tomography (PET), magnetic resonance imaging (MRI), & X-ray computed tomography (CT), the characterization of carrier-mediated transport and receptor kinetics, and high resolution pharmacokinetics. While in some experimental settings these can be examined in open (i.e., non-recirculating) systems, many experiments are performed in intact subjects, and their analysis requires the use of whole-body, recirculating models. The goal of this project is to develop a set of models for tracer transport and exchange that are sufficiently realistic to accurately account for observed anatomic and physiologic data for the behavior of a wide range of unmetabolized and metabolized substrates, ions, and hormones in the whole body. These models will be coded in a manner that the computation is rapid enough that they can be used for model fitting to data and parameter estimation on workstations rather than supercomputers. They will also be constructed so that they can be reduced to compartmental forms and can, thus, allow comparisons between physiologically realistic distributed models and traditional compartmental analysis.

模拟资源的一个中心目标是提供 了解血液-组织交换动力学的工具。的 特别感兴趣的是流出指示剂稀释技术、残留物 用于正电子发射断层扫描(PET)的技术，磁性 磁共振成像(MRI)、X射线计算机体层摄影(CT)、 载体介导的转运和受体动力学的特征， 和高分辨药代动力学。而在一些实验中 这些设置可以在开放(即，非再循环)中进行检查 系统，许多实验都是在完整的受试者身上进行的，他们的 分析需要使用全身循环模型。这个 该项目的目标是开发一套示踪剂模型 运输和交换足够现实，以准确地 解释观察到的解剖学和生理学数据的行为 广泛的未代谢和代谢的底物、离子和 全身的荷尔蒙。这些模型将以一种方式进行编码 计算速度足够快，可以用来建立模型 在工作站上进行数据拟合和参数估计，而不是 超级计算机。它们的建造也将使它们能够 简化为隔间形式，因此可以进行比较 在生理上逼真的分布式模型和传统模型之间 分区分析。