DIFFUSION FACILITATION IN TISSUES W/ BARRIER

促进扩散在文献中被认为是 主要作为在均匀介质中发生的过程。例外情况是 通过并行的路径来考虑这一点。更广阔的视野 这个问题是由那些对 血液中的运输和细胞对脂肪酸的摄取，这 与血液中的白蛋白和体内的脂肪酸结合蛋白结合 很多细胞。在这个项目中，我们将进行一系列的研究 关于这种扩散的复杂性逐渐增加 促进，特别是检查的速度的组合动力学 底物对载体蛋白的吸附和解吸 这些与药物跨膜转运速率之间的关系 各种机制。FAT涉及的过程概述 酸运输是由Bassingthwaighte等人提供的。()为 心。Fleischer(1986)和Burczynki等人。(1989年) 探索肝细胞摄取。进行精心安排的一系列演出 均质区域内溶质运移的研究进展 通过隔膜传输的系列产品。跨膜的 传输过程将包括不同类型的中介 运输，以及促进结合之间的复杂相互作用 具有特殊转运蛋白的同质区域中的分子 将被考虑。

Facilitated diffusion has been considered in the literature mainly as a process occurring in a homogeneous medium. The exception to this has been consideration via paths in parallel. A broader look at this problem has been initiated by those interested in the transport in the blood and the cellular uptake of fatty acids, which are bound to albumin in the blood and by fatty acid binding protein in many cells. In this project we will undertake a series of studies of gradually increasing complexity concerning such diffusional facilitation, specifically examining the combined kinetics of rates of adsorption and desorption of substrates to carrier proteins and the relationship between these and the rates of transmembrane transport by various mechanisms. An overview of the processes involved in fatty acid transport is provided by Bassingthwaighte et al. (1989) for the heart. Fleischer (1986) and, for example, Burczynki et al. (1989) explored hepatocyte uptake. To undertake a carefully staged sequence of studies on the transport of solutes within homogeneous regions in series with transport across barrier membranes. The transmembrane transport processes will include different types of mediated transport, and complex interactions between the facilitating binding molecules in the homogenous regions with the specialized transporters will be considered.