CARDIAC METABOLISM & FLOW

要完成的工作包括1。 一系列研究 表征心脏微血管形式的异质性， 局部血流，使用形态测量技术结合 基于微球的局部流量测量，使用新的分形 自相关技术来确定的方向性 局部流动之间的相关性，并确定流动异质性. 大心脏的高空间分辨率。 2. 的发展 用于解释来自15 O-氧的信号的分析方法， 15 O-水和15 O-一氧化碳残留函数（通过PET成像） 以及估算局部氧含量的方法 从这些心脏的消耗，并显示参数图像， 特征如局部氧代谢率、血管容积和 渗透率-表面积产品。 3. 一系列研究 确定心肌代谢的增加是否会降低 对照期间绵羊心脏总体血流异质性 肾上腺素能刺激和心房起搏。 这项研究，在 与领导下进行的PET成像研究合作 詹姆斯H。考德威尔需要放射性同位素服务支持 化学，PET成像物理学（设备维护和 软件开发）和成像程序，所有这些都在 与核医学和放射学人员合作。 4. 为研究提供放射化学、PET物理和成像支持 心脏代谢和血流（HL 50238）和心肌氧合 （HL52039）。

The work to be accomplished encompasses 1. A series of studies to characterize heterogeneities in cardiac microvascular form and regional blood flows, using morphonetric techniques combined with microsphere-based measures of local flow, using new fractal autocorrelation techniques to determine the directionality of the correlations among local flows, and determining flow heterogeneity at high spatial resolution in large hearts. 2. The development of methods of analysis for interpreting signals from 15O-oxygen, 15O-water, and 15O-carbon monoxide residue functions (by PET imaging) in the heart and the methods for estimating regional oxygen consumption from these hearts and displaying parametric images of such features as local oxygen metabolic rate, vascular volumes, and permeability-surface area products. 3. A series of studies to determine if increased myocardial metabolism reduces the degree of flow heterogeneity in the heart overall in sheep during control states, adrenergic stimulation and atrial pacing. This research, in collaboration with PET imaging studies performed under the leadership of James H. Caldwell requires service support in radioisotope chemistry, in physics of PET imaging (equipment maintenance and software development) and in imaging procedures, all of which are in collaboration with personnel in Nuclear Medicine and Radiology. 4. To provide radiochemistry, PET physics and imaging support for studies of cardiac metabolism and flow (HL50238) and myocardial oxygenation (HL52039).