COMPUTER ANALYSIS OF PRIMARY STRUCT OF DVMTLY REGULATED PROTEIN TYROSINE KINASES

DVMT调节蛋白酪氨酸激酶一级结构的计算机分析

• 批准号: 6282452
• 负责人: DAVID R BURGESS
• 金额: $ 1.17万
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282452
• 关键词: animal tissue; biomedical resource; growth /development; intestines

It has been shown by several labs including our own, that development of cells involves differential activity of certain protein tyrosine kinases. In order to study this further we are attempting to clone genes encoding tyrosine kinases from a cDNA library using immunological probes. Once the clones are isolated it will be necessary to identify them through sequence analysis. The sequences will then be compared to known sequences using existing libraries such as Genbank, etc. Using the sequence information thus acquired along with biochemical data about the activity of the proteins in cells in various states of differentiation, it should be possible to make some conclusions about the role(s) of the isolated gene products during development.

包括我们在内的几个实验室都证明了