SCHIZOTYPAL DISORDER: BIOL BASIS USING NEUROPSYCHOLOGICAL & MRI METHODS

分裂型人格障碍(SPD)具有内在的趣味性 一种人格障碍。它在理论上和实验上也是 作为精神分裂症谱系的一个可能组成部分很重要 疾病：最近的遗传流行病学研究提供了强有力的 SPD与精神分裂症(SZ)之间联系的证据，从而 强调研究SPD策略的实用性，以期 检查无并发症的SZ频谱异常，以及 深圳经常存在令人困惑的变量，如慢性病， 长期服药和长期住院。SPD受试者因此 我们相信，可能会提供一个更不混乱和更清晰的观点 至少一些“主要”光谱异常和/或标记物 比SZ受试者更易受伤害。因此，此应用程序 建议延长我们的多学科研究计划，以进行探索 SZ为研究SPD提供了生物学基础。我们认为这个焦点 对SPD来说特别及时，因为SPD的许多生物学特征 相关因素仍未得到检验。我们已经开发了临床， 神经心理学。事件相关电位(ERP)与磁场 共振成像(NM)方法，与我们的 我们认为，概念和理论方法已被证明是 在深圳的研究非常有成果。我们相信，这种处理SPD的方法将 事实证明同样富有成效，因为我们自己和其他人的数据都很强劲 提示至少在功能、临床和大脑方面 在这种谱系障碍中也可能存在SZ的异常。 我们新的初步和多学科SPD数据提供了我们 相信是惊人而令人兴奋的证据，证明了 在深圳出现的异常现象，我们认为很可能是 主要指的是颞叶，前额叶。皮质和TO 他们的联合系统。SPD受试者表现为：1)相对具体 词汇学习缺陷(主要是语义聚类) 加州口语学习考试(CVLT)及威斯康星州的发展趋势 卡片分类任务(WCST)异常；2)P300事件相关 潜在的总波幅降低和左、右颞叶 区域电压不对称(P300测量异常的处理 刺激)；以及3)左侧化体积减少的NM证据 前部海马区/杏仁体和邻近脑区扩大 临时号角。此应用程序建议确认并扩展 在一项对25名男性和25名女性进行的一项为期5年的右撇子研究中，这些发现 患有DSM-III-R SPD诊断和50个年龄、性别和父母的个人 AL-SES匹配的正常对照组。这个应用程序的可行性 我们相信，雄心勃勃的技术和理论目标是经过验证的 凭借我们在深圳的方法和途径方面的丰富经验 研究。

Schizotypal personality disorder (SPD) is of intrinsic interest as a personality disorder. It is also theoretically and experimentally important as a likely component of the schizophrenia spectrum disorders: recent genetic-epidemiologic studies have provided strong evidence of a link between SPD and schizophrenia (SZ), thereby emphasizing the utility of the strategy of studying SPD in order to examine the SZ spectrum abnormalities without the complicating, and often confounding variables present in SZ, such as chronic illness, chronic medication, and chronic hospitalization. SPD subjects thus may, we believe, provide a more non-confounded and clearer view of at least some of the "primary" spectrum abnormalities and/or markers of vulnerability than SZ subjects. Accordingly, this application proposes to extend our multidisciplinary research program for probing the biological bases of SZ to the study of SPD. We think this focus on SPD is particularly timely because many of SPD's biologic correlates remain unexamined. We have developed clinical, neuropsychological. event-related potential (ERP) and magnetic resonance imaging (NM) methodologies which, together with our conceptual and theoretical approach, have, we believe, proven to be very fruitful in SZ studies. We believe this approach to SPD will prove equally fruitful, since our own and others' data strongly suggest that at least some of the functional, clinical and brain abnormalities of SZ may also be present in this spectrum disorder. Our new preliminary and multidisciplinary SPD data provide what we believe is striking and exciting evidence for congruence with the abnormalities present in SZ, and which we think are likely to be primarily referable to temporal lobe, to prefrontal. cortex and to their joint systems. SPD subjects show: 1) a relatively specific deficit in verbal learning (primarily semantic clustering) on the California Verbal Learning Test (CVLT) and a trend toward Wisconsin Card Sorting Task (WCST) abnormalities; 2) P300 event-related potential overall amplitude reduction and a left < right temporal region voltage asymmetry (the P300 measures processing of unusual stimuli); and 3) NM evidence for left-lateralized reduction in volume of the anterior hippocampus/amygdala and enlargement of adjacent temporal horn. This application proposes to confirm and to extend these findings in a 5-year study of 25 male and 25 female right-handed individuals with DSM-III-R SPD diagnoses and 50 age-, sex-, and parent al SES-matched normal controls. The feasibility of this application's ambitious technical and theoretical goals, is, we believe, validated by our extensive experience with the methodology and approach in SZ research.