HUMAN CELL MUTAGEN FORMATION DURING THE THERMAL DESTRUCTION OF HAZARDOUS WASTES

描述：在热解过程中诱变剂的形成和 将确定超级基金场址的废物氧化情况，以便 为评估高温带来的潜在风险提供依据 销毁废物。待研究的代用废物已被 入选的原因是它们与Superfund网站总体上的相关性以及 尤其是阿伯乔纳遗址。感兴趣的产品包括： A)多环芳烃；b)氯化诱变剂；c)已知的前体多氯联苯 对二恶英和二苯并呋喃；d)亚微米级砷和铬气溶胶 和残留物。正在提议的项目的具体目标 是：(1)了解和控制负责的化学物质 诱变剂的形成，通过确定主要的分子量增长途径 这导致了生物活性物种的形成和它们 燃烧和热解体系中的多环前体，并获得 洞察氯对有机化合物化学途径的影响 副产品形成。(2)测定生物活性，使用 人体细胞突变分析，燃烧和热解产物，在 以提供有关潜在健康危害的指示 热销毁技术的应用。(三)试行提炼 可以用来解释实验的化学动力学模型 并预测不同燃烧条件下产物的形成 条件。(4)确定负责的参数 产品范围中的变化，并可用于 操作窗口的评估和控制策略的选择 目标是将健康风险降至最低，通过诱变性进行评估 由热解和氧化热破坏过程引起的研究。 研究活动将确定烟尘生长和诱变剂的途径 在氧化和热解高温环境中的形成 氯对诱变剂形成和分布的影响 温度对生长和碎裂机制的影响 化学物质的种类。拟议研究中将使用的方法 A)将进行热解研究，以确定 温度和时间对产品分布的覆盖温度 1,000至250,000之间；b)搅拌良好的/推流式反应器 两者的结合将确定热解反应与 燃烧器研究；c)模拟活动将使用分子 用于推广热解结果的模拟技术 研究；d)生物测定实验的设计将用于 确定在不同条件下产生的诱变剂的性质 条件；e)将使用反应堆模型来转换结果 到实用的系统。

Description: The formation of mutagens during the pyrolysis and oxidation of wastes at Superfund sites will be determined in order to provide a basis for assessing the potential risks from high temperature destruction of wastes. The surrogate wastes to be studied have been selected because of their relevance to Superfund sites in general and to the Aberjona site in particular. The products of interest will be: a) PAHs; b) chlorinated mutagens; c) PCBs, which are known precursors to dioxins and dibenzofurans; d) arsenic and chromium submicron aerosols and residual particles. The specific aims of the project being proposed are: (1) To understand and control the chemistry responsible for mutagen formation, by identifying major molecular weight growth pathways which lead to the formation of biologically active species and their polycyclic precursors in combustion and pyrolysis systems, and to gain insight on the effect of chlorine on the chemical pathways of organic by-product formation. (2) To determine the biological activities, using human cell mutation assays, of combustion and pyrolysis products, in order to provide an indication on potential health hazards related to the application of thermal destruction technologies. (3) To test and refine chemical kinetic models which can be used to interpret the experimental results and to forecast product formation in different combustion conditions. (4) To identify parameters that are responsible for variations in the product spectrum, and that are amenable for use in the evaluation of operating windows and the selection of control strategies with the objectives of minimizing health risks, assessed by mutagenicity studies, posed by pyrolytic and oxidative thermal destruction processes. Research activities will define the pathways to soot growth and mutagen formation in oxidative and pyrolytic high-temperature environments, on the effect of chlorine on mutagen formation and distribution, on the influence of temperature on the mechanisms of growth and fragmentation of chemical species. The methods to be used in the proposed studies are: a) Pyrolysis studies will be conducted to determine the effect of temperature and time on product distribution covering the temperature range of 1000 to 250,000; b) A well-stirred/plug-flow reactor combination will establish the relevance of the pyrolysis reaction to combustors studies; c) The modeling activity will use molecular simulation techniques to generalize the results of the pyrolysis studies; d) The design of the bioassay experiments will be used to determine the nature of the mutagens produced under the different conditions; e) Reactor modeling will be used to translate the results to practical systems.