COURSE OF CYCLOTHYMIA--ROLE COGNITION AND STRESS

循环性精神障碍的过程--角色认知和压力

• 批准号: 6185976
• 负责人: LYN Y ABRAMSON
• 金额: $ 56.88万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6185976
• 关键词: behavior prediction; behavioral /social science research tag; bipolar depression; bipolar depression depressed phase; bipolar depression manic phase; clinical research; cognition; cyclothymia; disease /disorder proneness /risk; human subject; interview; longitudinal human study; outcomes research; personality disorders; prognosis; psychometrics; quality of life; social support network; stress

Although much important biological research has been conducted on Bipolar disorder, little methodologically rigorous or theory guided work has examined psychosocial factors in the onset and course of this disorder. Moreover, although individuals exhibiting Cyclothymia, a subsyndromal form of bipolar disorder, are at high risk for developing full blown syndromal bipolar I or II disorder, little is known about: 1) the predictors of which cyclothymic individuals eventually do develop syndromal Bipolar disorder and which do not; or 2) the mechanisms involved in the development of syndromal Bipolar disorders among cyclothymics. Thus, the overarching goal of this proposal is to provide a theoretically consistent and methodologically rigorous examination of life events, cognitive processes, and personality factors in the course of Cyclothymia and initial onset and course of full blown syndromal Bipolar disorder among cyclothymics. The application of the cognitive diathesis-stress theories (Beck's theory and the Hopelessness theory), which have been so useful for unipolar depression, will be examined for cyclothymia and Bipolar disorder. To this end, a large scale, 3-year prospective study designed to examine life events, cognition, and personality factors in the course of cyclothymia and initial onset and course of Bipolar I or II disorder will be conducted. Three hundred Cyclothymics with not lifetime history of major depressive or full syndromal manic episodes and 300 demographically- matched normal controls with not lifetime history or any psychopathology will be followed prospectively with independent and blind self-report and interview assessments (every 16 weeks) of life events, cognition, and psychiatric status/symptoms in order to predict onset, course, and subsequent relapses/recurrences of syndromal and subsyndromal depression and mania. This study will contribute to: 1) knowledge about psychosocial factors in the course of Cyclothymia and initial onset and subsequent course of full blown bipolar disorder; 2) elucidation of the relationship between unipolar and bipolar depression; 3) development of interventions for treating and preventing bipolar disorder.

虽然许多重要的生物学研究已经进行， 双相情感障碍，很少有严格的方法或理论指导 工作已经检查了在发病和过程中的心理社会因素， 这种混乱。 此外，尽管个人表现出 循环性心境障碍是双相情感障碍的一种亚综合征形式， 发展为完全综合征双相I或II障碍的风险， 我们所知甚少：1）循环情感的预测因素 个体最终会发展为双相情感障碍综合征， （2）参与发展的机制 周期性心动过速综合征中的双相情感障碍 因此 该提案的总体目标是在理论上提供一个 对生活事件进行一贯的、方法上严格的检查， 认知过程和人格因素， 循环性心境障碍与全面综合征的初始发作和病程 周期性心动过速患者中的双相情感障碍。 的应用 认知素质-压力理论（贝克理论和 绝望理论），这对单极如此有用 抑郁症，将检查循环性心境障碍和双相情感障碍。 为此，进行了一项为期3年的大规模前瞻性研究， 在课程中检查生活事件，认知和个性因素 与双相I型或II型的初始发作和病程 将进行混乱。 300个没有循环的人 终生有重度抑郁或躁狂综合征史 300例人口统计学匹配的正常对照， 而不是一生的历史或任何精神病理学将被遵循 前瞻性地进行独立和盲法自我报告和访谈 评估（每16周）生活事件、认知和 精神状态/症状，以预测发病、病程和 综合征和亚综合征的后续复发/复发 抑郁和躁狂 本研究将有助于：1）了解心理社会 循环性心境障碍的病程和初发因素， 完全双相情感障碍的后续过程; 2）阐明 单相抑郁与双相抑郁的关系; 3） 制定治疗和预防双相情感障碍的干预措施 disorder.