COURSE OF CYCLOTHYMIA--ROLE COGNITION AND STRESS

循环性精神障碍的过程--角色认知和压力

• 批准号: 6392105
• 负责人: LYN Y ABRAMSON
• 金额: $ 49.64万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6392105
• 关键词: behavior prediction; behavioral /social science research tag; bipolar depression; bipolar depression depressed phase; bipolar depression manic phase; clinical research; cognition; cyclothymia; disease /disorder proneness /risk; human subject; interview; longitudinal human study; outcomes research; personality disorders; prognosis; psychometrics; quality of life; social support network; stress

Although much important biological research has been conducted on Bipolar disorder, little methodologically rigorous or theory guided work has examined psychosocial factors in the onset and course of this disorder. Moreover, although individuals exhibiting Cyclothymia, a subsyndromal form of bipolar disorder, are at high risk for developing full blown syndromal bipolar I or II disorder, little is known about: 1) the predictors of which cyclothymic individuals eventually do develop syndromal Bipolar disorder and which do not; or 2) the mechanisms involved in the development of syndromal Bipolar disorders among cyclothymics. Thus, the overarching goal of this proposal is to provide a theoretically consistent and methodologically rigorous examination of life events, cognitive processes, and personality factors in the course of Cyclothymia and initial onset and course of full blown syndromal Bipolar disorder among cyclothymics. The application of the cognitive diathesis-stress theories (Beck's theory and the Hopelessness theory), which have been so useful for unipolar depression, will be examined for cyclothymia and Bipolar disorder. To this end, a large scale, 3-year prospective study designed to examine life events, cognition, and personality factors in the course of cyclothymia and initial onset and course of Bipolar I or II disorder will be conducted. Three hundred Cyclothymics with not lifetime history of major depressive or full syndromal manic episodes and 300 demographically- matched normal controls with not lifetime history or any psychopathology will be followed prospectively with independent and blind self-report and interview assessments (every 16 weeks) of life events, cognition, and psychiatric status/symptoms in order to predict onset, course, and subsequent relapses/recurrences of syndromal and subsyndromal depression and mania. This study will contribute to: 1) knowledge about psychosocial factors in the course of Cyclothymia and initial onset and subsequent course of full blown bipolar disorder; 2) elucidation of the relationship between unipolar and bipolar depression; 3) development of interventions for treating and preventing bipolar disorder.

尽管许多重要的生物学研究已经在

项目成果

Social rhythm regularity and the onset of affective episodes in bipolar spectrum individuals.

• DOI: 10.1111/j.1399-5618.2008.00583.x
• 发表时间: 2008-06
• 期刊: Bipolar disorders
• 影响因子: 5.4
• 作者: Gail H C Shen;L. Alloy;L. Abramson;L. Sylvia

Kindling of Life Stress in Bipolar Disorder: Effects of Early Adversity.

双相情感障碍的生活压力的点燃：早期逆境的影响。

• DOI: 10.1016/j.beth.2016.12.003
• 发表时间: 2017
• 期刊: Behavior therapy
• 影响因子: 3.7
• 作者: Shapero,BenjaminG;Weiss,RachelB;Burke,TaylorA;Boland,ElaineM;Abramson,LynY;Alloy,LaurenB
• 通讯作者: Alloy,LaurenB

Development of gender differences in depression: an elaborated cognitive vulnerability-transactional stress theory.

• DOI: 10.1037/0033-2909.127.6.773
• 发表时间: 2001-11
• 期刊: Psychological bulletin
• 影响因子: 22.4
• 作者: B. Hankin;L. Abramson

The role of lifetime anxiety history in the course of bipolar spectrum disorders.

终生焦虑史在双相谱系障碍病程中的作用。

• DOI: 10.1016/j.psychres.2018.03.087
• 发表时间: 2018
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Titone,MadisonK;Freed,RachelD;O'Garro-Moore,JaredK;Gepty,Andrew;Ng,TommyH;Stange,JonathanP;Abramson,LynY;Alloy,LaurenB
• 通讯作者: Alloy,LaurenB

Progression along the bipolar spectrum: a longitudinal study of predictors of conversion from bipolar spectrum conditions to bipolar I and II disorders.

沿双极光谱的进展：从双极光谱条件转换为双极I和II疾病的纵向研究。

• DOI: 10.1037/a0023973
• 发表时间: 2012-02
• 期刊: Journal of abnormal psychology
• 影响因子: 4.6
• 作者: Alloy LB;Urošević S;Abramson LY;Jager-Hyman S;Nusslock R;Whitehouse WG;Hogan M
• 通讯作者: Hogan M