BAS and Bipolar Spectrum: Biopsychosocial Integration

BAS 和双极谱：生物心理社会整合

• 批准号: 6998460
• 负责人: LYN Y ABRAMSON
• 金额: $ 42.64万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998460
• 关键词: behavior prediction; behavioral /social science research tag; bipolar depression; clinical research; cognition; cyclothymia; disease /disorder onset; electroencephalography; human subject; interview; lifestyle; longitudinal human study; major depression; mental disorder diagnosis; mental disorder prevention; mental health epidemiology; pathologic process; personality; psychobiology; psychological tests; psychopathology; relapse /recurrence; social psychology; social support network

DESCRIPTION (provided by applicant): This application is part of a 2-site collaborative renewal grant with an identical (except for budget/personnel) application submitted concurrently by Dr. Lauren B. Alloy (Temple University) under the same title. Although important biological work has been conducted on Bipolar (Bi) disorder, less work has examined psychosocial factors in the onset, course, and progression of this disorder. Thus, in this proposal, theories implicating the Behavioral Approach System (BAS) in Bi Spectrum disorders are integrated with work on psychosocial factors in these conditions to provide a theoretically consistent and methodologically rigorous biopsychosocial framework to guide a prospective study of the course and progression of Bi disturbance. In the current grant, a unique sample of 206 Ss initially exhibiting milder Bi disturbance (Cyclothymia [Cyc] and Bi II), many of whom now are progressing to a more severe course, and 214 demographically-matched Normal controls (Nors) with no lifetime history of any psychopathology has been assembled and followed prospectively for an average of 21 months with independent and blind self-report and interview assessments (every 16 weeks) of life events, cognition, and psychiatric status/symptoms. At the outset of the proposed continued follow-up of this sample, laboratory assessments of BAS profiles, both in the resting state and in response to BAS-relevant cues, using psychophysiological (EEG assessments of left frontal cortical activity), behavioral (task persistence vs. helplessness), cognitive (self-efficacy/hopefulness vs. hopelessness), and subjective affect (euphoria, anger/irritability, depression) indices will be conducted to test the hypothesis that Bi Ss exhibit dysregulated BAS activity compared to Nor Ss. Moreover, life events, with a focus on those that are BAS-relevant, laboratory BAS profile, and cognitive vulnerability will be examined in the prediction of -Hypomania/Mania and Depression symptoms and episodes among Bi and Nor Ss in the continued 3-year prospective follow-up. Finally, these same factors will be examined to predict general worsening of course and progression to Bi II and Bi I status among the Bi Ss.

描述（由申请人提供）：本申请是2个研究中心合作续期补助金的一部分，Lauren B博士同时提交了相同的（预算/人员除外）申请。Alloy（Temple University），同名。 虽然重要的生物学工作已经进行了双相（Bi）障碍，较少的工作已经审查了心理社会因素的发病，病程和进展，这种疾病。因此，在这项建议中，理论牵连的行为方法系统（BAS）在双频谱障碍与工作的心理社会因素在这些条件下，提供一个理论上一致的和方法上严格的生物心理社会框架，以指导一个前瞻性的研究过程和发展的Bi干扰。在目前的补助金中，206个Ss的独特样本最初表现出较温和的Bi干扰，（循环性心境障碍[Cyc]和Bi II），其中许多人现在正在进展到更严重的过程，和214个人口统计学上匹配的正常对照（Nors），没有任何精神病理学的终身病史，并进行了平均21个月的前瞻性随访，进行了独立和盲法自我报告和访谈评估（每16周）的生活事件，认知和精神状态/症状。在开始对该样本进行持续随访时，使用心理生理学方法对静息状态下和对BAS相关线索的反应中的BAS概况进行实验室评估。（左额叶皮质活动的EEG评估），行为（任务持续性与无助），认知（自我效能/绝望与绝望）和主观情感（欣快、愤怒/易怒、抑郁）指数来检验与Nor Ss相比Bi Ss表现出失调的BAS活性的假设。此外，生活事件，重点是那些BAS相关的，实验室BAS配置文件，和认知脆弱性将在预测-轻躁狂/躁狂和抑郁症状和发作的Bi和Nor Ss在持续3年的前瞻性随访检查。最后，将检查这些相同的因素，以预测Bi S患者病程的一般恶化以及进展为Bi II和Bi I状态。