PREVENTION OF CHRONIC ASTHMA IN YOUNG CHILDREN

预防幼儿慢性哮喘

• 批准号: 6170421
• 负责人: Mary D. Klinnert
• 金额: $ 26.65万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6170421
• 关键词: airborne allergen; antiinflammatory agents; asthma; case history; child behavior; clinical research; disease /disorder prevention /control; health care cost /financing; health care service utilization; home health care; human subject; immunoglobulin E; infant human (0-1 year); low socioeconomic status; maternal behavior; middle childhood (6-11); nursing intervention; preschool child (1-5); quality of life; respiratory infections

DESCRIPTION: The goal of this five year research demonstration and education project is to determine if an intensive intervention using nurse home visitors can reduce asthma prevalence among children from low income households who begin wheezing in infancy. One hundred eighty infants and their parents who are Medicaid-eligible will be recruited from public health settings. About half of the children will be from minority families. Families will be randomly assigned to a nurse home visitor intervention group or a control group. In the intervention group, nurse home visitors will work with parents for one year to target allergens in the home, reduce environmental tobacco smoke, and improve the quality of maternal caregiving, particularly as it relates to asthma prevention and management. A control group will receive information related to preventing asthma. Repeated assessments of the targeted variables will be made in both groups. In addition, family history of asthma and children's IgE levels at enrollment will be assessed, since these variables are expected to interact with the targeted variables to affect outcome. Maternal psychological resources also will be assessed, as this factor has been associated with responsivity to home visitor interventions. Respiratory infections and use of anti-inflammatory medications will be monitored as possible mediating variables. All children will be followed to 4 years of age. Outcomes to be measured include asthma status, functional severity of asthma by maternal report and by cumulative symptom reports, pulmonary functions and IgE levels, quality of life and child behavioral adjustment, and health care use and costs. The principal investigator is Mary Klinnert, Ph.D., who is Chief of Pediatric Psychology at the National Jewish Center for Immunology and Respiratory Medicine and Associate Professor of Psychiatry at the University of Colorado Health Sciences Center. Co-investigators are Lanny Rosenwasser, M.D., Larry Borish, M.D., and Andy Liu, M.D.

描述：本研究的目标是五年的示范和 教育项目是确定是否使用护士进行强化干预， 家庭访视可以降低低收入儿童的哮喘患病率 在婴儿期开始喘息的家庭。 一百八十个婴儿， 符合医疗补助条件的父母将从公共卫生部门招募 设置. 大约一半的孩子将来自少数民族家庭。 家庭将被随机分配到护士之家访问者干预 组或对照组。 在干预组中， 将与家长合作一年，以针对过敏原在家里，减少 环境烟草烟雾，提高产妇分娩质量， 特别是当其涉及哮喘预防和管理时。 控制 小组将收到有关预防哮喘的信息。 重复 将对两组的目标变量进行评估。 在 此外，哮喘家族史和儿童入组时的IgE水平 将进行评估，因为预计这些变量将与 有针对性的变量来影响结果。 产妇心理资源也 将进行评估，因为这一因素与以下方面的反应有关： 家访干预。 呼吸道感染和使用 将监测抗炎药物，尽可能介导 变量 所有儿童将被随访至4岁。 结果将是 测量包括哮喘状态、母亲哮喘的功能严重程度、 报告和累积症状报告、肺功能和IgE 水平、生活质量和儿童行为调整以及医疗保健使用 和成本。 主要研究者是玛丽克林纳特博士，他是 国家犹太免疫学中心的儿科心理学， 大学呼吸内科和精神病学副教授 科罗拉多健康科学中心。 合作调查者是兰尼·罗森瓦瑟， 医学博士，Larry Borish医学博士Andy Liu，M.D.