Identifying the mechanisms for the effects of air pollution on cardiopulmonary disease in Beijing, China

确定中国北京空气污染对心肺疾病影响的机制

• 批准号: NE/S006729/2
• 负责人: Frank Kelly
• 金额: $ 19.07万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FS006729%2F2
• 关键词: Identifying; mechanisms; effects; air; pollution

Large cities in China, including the capital city of Beijing, and their surrounding areas have some of the highest air pollution levels in the world. With over one half of China's population now living in cities, air pollution and air quality are important local and national policy issues. At the same time, China is undergoing changes in health: Deaths in children have come down impressively, and people live to older ages when diseases of the heart and the lung are more common and important. Air pollution in cities is one of the main causes of health problems and disease in China, with especially large effects on the heart and the lung.We know from research in Europe and North America that air pollution adversely affects human health, but we know little about how and why this happens, and whether air pollution from different sources has more or less effects. Even less is known about what these mechanisms are in China, where air pollution may be from different sources and therefore have different chemistry. This knowledge is important for deciding what the most effective strategies to reduce the health effects of air pollution are. In this research project, leading scientists from China and the United Kingdom will work closely to use modern methods in epidemiology and biological sciences to better understand which components of air pollution affects human health in China, and how these effects occur. This knowledge will be used together with information from our related research projects to identify the most effective ways of protecting human health from air pollution in Chinese cities.

包括首都北京在内的中国大城市及其周边地区的空气污染水平是世界上最高的。由于中国一半以上的人口居住在城市，空气污染和空气质量是重要的地方和国家政策问题。与此同时，中国的健康状况正在发生变化：儿童死亡率大幅下降，人们活到老年，心脏和肺部疾病更加常见和重要。城市空气污染是中国健康问题和疾病的主要原因之一，对心脏和肺的影响尤其大。我们从欧洲和北美的研究中了解到，空气污染对人体健康有不利影响，但我们对这种情况如何发生以及为什么会发生，以及不同来源的空气污染是否会产生或多或少的影响知之甚少。中国的空气污染可能来自不同的来源，因此具有不同的化学性质。这些知识对于决定减少空气污染对健康影响的最有效策略是什么非常重要。在这个研究项目中，来自中国和英国的顶尖科学家将密切合作，利用流行病学和生物科学的现代方法，更好地了解空气污染的哪些成分会影响中国的人类健康，以及这些影响是如何发生的。这些知识将与我们相关研究项目的信息一起使用，以确定保护中国城市空气污染中人类健康的最有效方法。

项目成果

Personal exposure to air pollution and respiratory health of COPD patients in London.

• DOI: 10.1183/13993003.03432-2020
• 发表时间: 2021-07
• 期刊: The European respiratory journal
• 作者: Evangelopoulos D;Chatzidiakou L;Walton H;Katsouyanni K;Kelly FJ;Quint JK;Jones RL;Barratt B
• 通讯作者: Barratt B

The role of burden of disease assessment in tracking progress towards achieving WHO global air quality guidelines.

• DOI: 10.1007/s00038-020-01479-z
• 发表时间: 2020-11
• 期刊: International journal of public health
• 影响因子: 4.6
• 作者: Evangelopoulos D;Perez-Velasco R;Walton H;Gumy S;Williams M;Kelly FJ;Künzli N
• 通讯作者: Künzli N

Exposure to Elevated Nitrogen Dioxide Concentrations and Cardiac Remodeling in Patients With Dilated Cardiomyopathy.

• DOI: 10.1016/j.cardfail.2021.11.023
• 发表时间: 2022-06
• 期刊: Journal of cardiac failure
• 影响因子: 6

Our change of Co-Editor-in-Chief and the journal's prospects

我们的联合主编的变动以及期刊的前景

• DOI: 10.1007/s11869-019-00761-1
• 发表时间: 2019
• 期刊: Air Quality, Atmosphere & Health
• 作者: Chung Y