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MOUSE MODEL--TARGETED GENE KNOCK OUT OF CYTOSOLIC PHOSPHOLIPASE A2

MOUSE MODEL--TARGETED GENE KNOCK OUT OF CYTOSOLIC PHOSPHOLIPASE A2
小鼠模型——胞质磷脂酶 A2 的靶向基因敲除
批准号：
6162135
负责人：
R LANGENBACH
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6162135
关键词：
active sites carcinogen testing carcinogens complementary DNA cytoplasm disease /disorder model electroporation gene mutation gene targeting genetic recombination genetically modified animals inflammation laboratory mouse neoplasm /cancer nucleic acid sequence phospholipase A2

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Summary of Work: The disruption of the mouse gene encoding cPLA2 by homologous recombination is currently in progress. Mice deficient in functional cPLA2 will be generated by targeting the region of the gene encoding the active site of the enzyme at serine 228 which is known to be essential for enzymatic activity. A targeting construct is being electroporated into embryonic stem cells and targeted cells injected into 2.5 day old mouse blastocysts to produce chimeras. Mice deficient in cPLA2 will be used to determine the function of the enzyme in cancer and inflammation.
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TRANSFECTION OF CDNAS FOR DRUG METABOLIZING ENZYMES
MOUSE MODEL--TARGETED GENE KNOCK-OUT OF PROSTAGLANDIN SYNTHASE I AND II
MOUSE MODEL--TARGETED GENE KNOCK OUT OF CYTOSOLIC PHOSPHOLIPASE A2
TRANSFECTION OF CDNAS FOR DRUG METABOLIZING ENZYMES
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