课题基金 / 基金详情

ONCOGENIC ACTIVITY OF RETROVIRAL VECTORS USED IN HUMAN GENE THERAPY

ONCOGENIC ACTIVITY OF RETROVIRAL VECTORS USED IN HUMAN GENE THERAPY
人类基因治疗中使用的逆转录病毒载体的致癌活性
批准号：
3855873
负责人：
R LANGENBACH
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3855873
关键词：
Retroviridae cell transformation drug adverse effect embryo /fetus tissue /cell culture gene therapy human genetic material tag laboratory mouse oncogenes transposon /insertion element

项目摘要

项目成果

R LANGENBACH的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Retroviral vectors containing cDNAs for the expression of appropriate genes have been proposed or use in correcting an/or alleviating certain human diseases. However, little is known about possible adverse effects of the proposed vectors. In collaboration with scientists at NHLBI, NIH and Genetic Therapy, Inc., we are investigating the ability of retroviral vectors to cause morphological transformation and altered differentiation of mouse embryo C3H/10T-(one-half) cells. In several studies conducted to date, one retroviral vector construct has not been shown to cause the morphological transformation of C3H/10T-(one-half) cells. Further studies to determine possible biological effects of this and other retroviral vectors are in progress.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
TRANSFECTION OF CDNAS FOR DRUG METABOLIZING ENZYMES
MOUSE MODEL--TARGETED GENE KNOCK-OUT OF PROSTAGLANDIN SYNTHASE I AND II
MOUSE MODEL--TARGETED GENE KNOCK OUT OF CYTOSOLIC PHOSPHOLIPASE A2
TRANSFECTION OF CDNAS FOR DRUG METABOLIZING ENZYMES
海外基金