NOVAL HUMAN MACROPHAGE RECEPTOR

新型人类巨噬细胞受体

• 批准号: 6162950
• 负责人: J M SAAVEDRA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162950
• 关键词: brain cell; experimental brain lesion; genetic library; human genetic material tag; human tissue; laboratory rat; macrophage; microglia; molecular cloning; nerve injury; neural degeneration; receptor binding; receptor expression

We have used the selective ligand CGP 42112 to modulate the novel macrophage-microglial receptor described by our group in human monocytes/macrophages and in lesions of the rat brain. We found that CGP 42112 antagonizes the macrophage stimulation produced by lipopolysacharide, inhibiting the cytokine and metalloprotein ase-g production by human macrophages. These results may suggest that CGP 42112 and related compounds can have anti-immune, anti-inflammatory properties. We have also showed that CGP 42 112 binding sites are expressed in the adventitia of balloon-catheterized arteries, suggesting a role for these receptors in the inflammatory reaction to arterial injury. In the rat brain, physical and chemical lesions result in expression of CGP 42112 receptors, and this is associated with neuronal death, both at the site of the lesion and distal to the lesion, reflecting degeneration of projecting neuronal terminals. We suggest a role for CGP 42112 receptors in the mechanisms of neuronal injury and repair. We continue our efforts to clone the novel macrophage/microglia receptor from a cDNA library from human monocytes and rat spleen.

我们使用了选择性配体CGP 42112来调节这种新物质