PERIPHERAL AND CENTRAL CATECHOLAMINES IN HYPERTENSION AND STRESS

外周和中枢儿茶酚胺在高血压和压力中的作用

• 批准号: 4696335
• 负责人: J M SAAVEDRA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696335
• 关键词: angiotensin /renin /aldosterone hypertension; angiotensin II; brain metabolism; brain stem; cardiovascular function; cardiovascular pharmacology; catecholamines; disease /disorder model; high performance liquid chromatography; hypertension; immunofluorescence technique; neuroendocrine system; neurohypophysis; neuropharmacology; neurotransmitter metabolism; peptidyl dipeptidase A; psychological stressor; radioimmunoassay; renin angiotensin system; stress; vasopressins

We studied the role of peripheral and central catecholamines and angiotensin II in the regulation of cardiovascular function. We established that specific brain areas containing adrenaline neurons control both catecholamine and vasopressin release and influence blood pressure and heart rate. We determined the precise source of intermediate and posterior lobe pituitary catecholamines. There are close interactions between beta-adrenergic receptors and arterial angiotensin-converting enzyme. The brain angiotensin system, both at the converting enzyme and at the receptor levels, is involved in cardiovascular control in the spontaneously hypertensive rat.

我们研究了外周和中枢儿茶酚胺的作用和 血管紧张素II在心血管功能调节中的作用 我们发现大脑中含有肾上腺素神经元的特定区域 控制儿茶酚胺和加压素的释放并影响血液 血压和心率。 我们确定了中间叶和后叶的确切来源 脑垂体儿茶酚胺。 β-肾上腺素能受体与动脉有密切的相互作用 血管紧张素转换酶。 脑血管紧张素系统，在转换酶和在 受体水平，是参与心血管控制的自发 高血压大鼠。