ROLE OF NEUROPEPTIDES AND BIOGENIC AMINES IN NEUROENDOCRINE REGULATION

神经肽和生物胺在神经内分泌调节中的作用

• 批准号: 3944635
• 负责人: J M SAAVEDRA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944635
• 关键词: analytical method; angiotensin II; atrial natriuretic peptide; autonomic nervous system; autoradiography; brain metabolism; cardiovascular function; disease /disorder model; dopamine; heart conduction system; high performance liquid chromatography; hormone regulation /control mechanism; immunity; immunochemistry; neuroendocrine system; neuropharmacology; neurotransmitter metabolism; neurotransmitters; pituitary gland; psychobiology; radioimmunoassay

With the use of quantitative autoradiography, we studied the role of neuropeptides (angiotensin II, atrial natriuretic peptide) and biogenic amines (dopamine) in the central regulation of autonomic nervous system and pituitary gland. We also studied the role of neuropeptides in the regulation of the immune response by localizing neuropeptide receptors in immune organs and immune cells and by investigating the second messenger response. We demonstrated a role for central angiotensin II and atrial natriuretic peptide in the control of cardiovascular function. These neuropeptides may also be involved in regulation of the immune response. Specific angiotensin II and beta-adrenoceptors were quantified in the rat heart conduction system. New methods were developed to study localization and transport of D1 and D2 dopamine receptors in brain, and to study localization of malignant melanomas. Psychotomimetic phenylisopropylamine receptors were localized and quantified in selective brain areas.

通过使用定量放射自显影技术，我们研究了 神经肽（血管紧张素 II、心房钠尿肽）和 生物胺（多巴胺）在自主神经的中枢调节中的作用 神经系统和脑下垂体。 我们还研究了角色 神经肽通过调节免疫反应 定位免疫器官和免疫系统中的神经肽受体 细胞并通过研究第二信使反应。 我们证明了中枢血管紧张素 II 和心房的作用 利尿钠肽控制心血管功能。 这些神经肽也可能参与调节 免疫反应。 特定血管紧张素 II 和 β-肾上腺素受体 在大鼠心脏传导系统中进行量化。 新方法 开发用于研究 D1 和 D2 的定位和运输 大脑中的多巴胺受体，并研究其定位 恶性黑色素瘤。 拟精神病药苯基异丙胺 受体在选择性大脑区域进行定位和量化。