ROLE OF NEUROPEPTIDES AND BIOGENIC AMINES IN NEUROENDOCRINE REGULATION

利用定量放射自显影，我们研究了 神经肽（血管紧张素II，心房利钠肽）和 生物胺（多巴胺）在自主神经中枢调节 神经系统和脑下垂体。 我们还研究了 神经肽在免疫反应调节中的作用 定位免疫器官中的神经肽受体和免疫 细胞和研究第二信使反应。 我们证实了中枢血管紧张素II和心房肌纤维化的作用。 利钠肽对心血管功能的控制。 这些神经肽也可能参与调节 免疫反应 特异性血管紧张素II和β-肾上腺素受体 在大鼠心脏传导系统中进行定量。 新方法 用于研究D1和D2的定位和转运 多巴胺受体，并研究定位 恶性黑素瘤 拟精神病药苯异丙胺 在选择的脑区域中定位和定量受体。

With the use of quantitative autoradiography, we studied the role of neuropeptides (angiotensin II, atrial natriuretic peptide) and biogenic amines (dopamine) in the central regulation of autonomic nervous system and pituitary gland. We also studied the role of neuropeptides in the regulation of the immune response by localizing neuropeptide receptors in immune organs and immune cells and by investigating the second messenger response. We demonstrated a role for central angiotensin II and atrial natriuretic peptide in the control of cardiovascular function. These neuropeptides may also be involved in regulation of the immune response. Specific angiotensin II and beta-adrenoceptors were quantified in the rat heart conduction system. New methods were developed to study localization and transport of D1 and D2 dopamine receptors in brain, and to study localization of malignant melanomas. Psychotomimetic phenylisopropylamine receptors were localized and quantified in selective brain areas.