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PERIPHERAL AND CENTRAL CATECHOLAMINES IN HYPERTENSION AND STRESS

PERIPHERAL AND CENTRAL CATECHOLAMINES IN HYPERTENSION AND STRESS
外周和中枢儿茶酚胺在高血压和压力中的作用
批准号：
3968434
负责人：
J M SAAVEDRA
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3968434
关键词：
angiotensin /renin /aldosterone hypertension angiotensin II brain metabolism brain stem cardiovascular function cardiovascular pharmacology catecholamines disease /disorder model high performance liquid chromatography hypertension hypothalamus immunofluorescence technique neuroendocrine system neurohypophysis neuropharmacology neurotransmitter metabolism peptidyl dipeptidase A psychological stressor radioimmunoassay renin angiotensin system stress vasopressins

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英文摘要
We studied the role of peripheral and central catecholamines and angiotensin II in the regulation of cardiovascular function. We established that specific brain areas containing adrenaline neurons control both catecholamine and vasopressin release and influence blood pressure and heart rate. We determined the precise source of intermediate and posterior lobe pituitary catecholamines. There are close interactions between beta-adrenergic receptors and arterial angiotensin-converting enzyme. The brain angiotensin system, both at the converting enzyme and at the receptor levels, is involved in cardiovascular control in the spontaneously hypertensive rat.
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