PERIPHERAL AND CENTRAL CATECHOLAMINES IN HYPERTENSION AND STRESS

外周和中枢儿茶酚胺在高血压和压力中的作用

• 批准号: 3968434
• 负责人: J M SAAVEDRA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968434
• 关键词: angiotensin /renin /aldosterone hypertension; angiotensin II; brain metabolism; brain stem; cardiovascular function; cardiovascular pharmacology; catecholamines; disease /disorder model; high performance liquid chromatography; hypertension; hypothalamus; immunofluorescence technique; neuroendocrine system; neurohypophysis; neuropharmacology; neurotransmitter metabolism; peptidyl dipeptidase A; psychological stressor; radioimmunoassay; renin angiotensin system; stress; vasopressins

We studied the role of peripheral and central catecholamines and angiotensin II in the regulation of cardiovascular function. We established that specific brain areas containing adrenaline neurons control both catecholamine and vasopressin release and influence blood pressure and heart rate. We determined the precise source of intermediate and posterior lobe pituitary catecholamines. There are close interactions between beta-adrenergic receptors and arterial angiotensin-converting enzyme. The brain angiotensin system, both at the converting enzyme and at the receptor levels, is involved in cardiovascular control in the spontaneously hypertensive rat.

我们研究了外周和中枢儿茶酚胺的作用