INSTRUMENTAL LEARNING AND TOLERANCE TO STIMULANTS

工具学习和对兴奋剂的耐受性

• 批准号: 6164349
• 负责人: David Wolgin
• 金额: $ 16.86万
• 依托单位: FLORIDA ATLANTIC UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至 2001-12-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6164349
• 关键词: amphetamines; anorexia; apomorphine; behavior test; behavioral /social science research tag; body movement; central nervous system stimulants; cocaine; discrimination learning; drug addiction; drug tolerance; fenfluramine; laboratory rat; nutrient intake activity; nutrition related tag; operant conditionings; psychopharmacology

DESCRIPTION: (Applicant's Abstract) By definition, addiction is characterized by chronic drug administration. Much remains to be learned, however, about the way stimulant drugs affect behavior under chronic conditions. The long-term objective of the proposed research is to understand the mechanisms by which tolerance develops to the hypophagic effect of these drugs. Our working hypothesis is that tolerance is mediated by two sequential processes: 1) recovery from anorexia and (2) learning to suppress stereotyped movements, which interfere with feeding. The two processes can be analyzed by comparing the effects of stimulant drugs on the milk intakes of cannula- and bottled-fed rats. Because stereotyped movements do not interfere with the ingestion of milk in cannula-fed rats, the suppression of feeding can be attributed to the anorexic effect of the drug. In bottle-fed rats, however, both anorexia and stereotypy contribute to the suppression of feeding. The specific aims of the project are: (1) To demonstrate that recovery from anorexia is a prerequisite to learning to suppress stereotyped movements. Thus, tolerance should transfer from the bottle condition to the cannula condition, but not vice versa. (2) To determine whether tolerance to the anorexic effects of stimulants is contingent on having access to milk in the drugged state. (3) To explore the boundary conditions for learning to suppress stereotyped movements. The effect of various doses of amphetamine on the ability of rats to maintain a stationary head position that is reinforced with intraoral milk infusions will be investigated. (4) To determine whether rats can learn to suppress stereotyped movements induced by cocaine cathinone, and apomorphine. 5) To understand the conditions responsible for the dissipation of tolerance in bottle- and (6) cannula-fed rats. The relatively rapid development of tolerance to the behaviorally disruptive effects of stimulant drugs may contribute to their widespread abuse. To the extent that behavioral tolerance involves instrument learning, the proposed research will provide a rationale for understanding how people adapt to the behaviorally disruptive effects of these drugs.

描述：（申请人摘要） 根据定义，成瘾的特征是长期服用药物。 然而，关于兴奋剂药物影响的方式还有很多东西有待了解。 慢性条件下的行为。 拟议的长期目标 研究的目的是了解耐受性发展到耐受性的机制 这些药物的抑制吞咽作用。 我们的工作假设是宽容 由两个连续过程介导：1）厌食症恢复和（2） 学习抑制会干扰进食的刻板动作。 可以通过比较兴奋剂的效果来分析这两个过程 药物对插管和瓶饲大鼠牛奶摄入量的影响。 因为 定型动作不会干扰乳汁的摄入 插管喂养的大鼠，进食的抑制可归因于 该药物的厌食作用。 然而，在奶瓶喂养的老鼠中，厌食症和 刻板印象会抑制进食。 具体目标 该项目是：（1）证明厌食症的恢复是一个 学习抑制定型运动的先决条件。 因此，耐受性 应该从瓶子状态转移到插管状态，但不是 反之亦然。 (2) 确定是否耐受厌食作用 兴奋剂取决于在服药状态下是否能喝到牛奶。 (3) 探索学习抑制刻板印象的边界条件 动作。 不同剂量的安非他明对能力的影响 大鼠保持固定的头部位置，并用 将调查口内输奶。 (4)判断是否 老鼠可以学会抑制可卡因引起的刻板运动 卡西酮和阿扑吗啡。 5）了解负责的条件 奶瓶喂养和（6）插管喂养的大鼠的耐受性消失。 对破坏性行为的容忍度发展得相对较快 兴奋剂药物的作用可能导致其广泛滥用。 至 在行为容忍涉及工具学习的程度上，拟议的 研究将为理解人们如何适应 这些药物的行为破坏作用。