TRAINING IN MOLECULAR VIROLOGY AND PATHOGENESIS

描述（改编自应用程序）：该计划的目的是 提供全面的分子病毒学博士前培训， 通过将课程工作中的坚实基础与研究相结合， 广泛的病毒学领域的经验。支持五名博士生， 包括两名DVM学生。参加该计划的学员将 根据他们的本科（或DVM）背景的强度选择， 生物科学的研究经验和研究中的职业目标 病毒学 所有学员将参加病毒学核心课程， 其他相关学科，如分子生物学，生物化学， 免疫学，伦理问题和专业的必修课 责任，他们将参加一个研讨会系列，期刊俱乐部 研究撤退。研究生培训将通过 研究撤退。研究生培训将通过 康奈尔大学研究生院-研究生教育领域比较 生物医学;微生物学;生物化学、分子和细胞生物学; 和遗传学和发展论文研究将在其中一个进行 八个实验室的参与教师谁拥有主要任命 在兽医学院，分子生物学系和 遗传学或博伊斯汤普森研究所。对拟议的 该计划是实质性的形式的研究环境和设施， 康奈尔生物技术计划以及计算机和图书馆系统。 可供培训的领域集中在病毒复制和组装， 基因表达和发病机制。这些研究包括逆转录病毒， 疱疹病毒和嗜肝DNA病毒肿瘤发生，逆转录病毒诱导 免疫缺陷、逆转录病毒RNA包装和衣壳结构， 组装，杆状病毒-基因调控和表达，疱疹病毒和 流感病毒基因组包装和细胞内转运，细小病毒 嗜性和衣壳晶体结构，以及疱疹病毒和 嗜肝DNA病毒疫苗和抗病毒药物开发。在猫的体内模型中， 鸟类、鼠类、鱼类、松鼠和犬科动物可用于评估 病毒感染的发病机制。

DESCRIPTION (adapted from the application): The purpose of this program is to provide comprehensive predoctoral training in molecular virology and pathogenesis by coupling a strong foundation in coursework with research experience in broad areas of virology. Support for five predoctoral students, including two DVM students is requested. Trainees entering the program will be selected based upon the strength of their undergraduate (or DVM) backgrounds, research experience in the biological sciences and career goals in the study of virology. All trainees will take virology core courses, various advanced courses in other relevant disciplines such as molecular biology, biochemistry, and immunology, a mandatory course on Ethical Issues and Professional Responsibilities, and they will participate in a seminar series, journal club and research retreat. Graduate- student training will be administered through and research retreat. Graduate- student training will be administered through the Cornell Graduate School - the Fields of Graduate Education Comparative Biomedical Sciences; Microbiology; Biochemistry, Molecular and Cell Biology; and Genetics and Development Thesis research will be performed in one of the eight laboratories of the participating faculty who have primary appointments in the College of Veterinary Medicine, the Department of Molecular Biology and Genetics or the Boyce Thompson Institute. Existing support for the proposed program is substantial in the form of the research environment and facilities, the Cornell Biotechnology Program and computing and library systems. Areas available for training are centered on viral replication and assembly, gene expression and pathogenesis. These studies encompass retroviral, herpesviral and hepadnaviral oncogenesis, retrovirus-induced immunodeficiencies, retroviral RNA packaging and capsid structure and assembly, baculovirus- gene regulation and expression, herpesvirus and influenza virus genome packaging and intracellular transport, parvovirus tropism and capsid crystallographic structure, and herpesvirus and hepadnavirus vaccine and antivirals development. In vivo models of feline, avian, murine, piscine, sciurid, and canine species are available to assess pathogenesis of viral infections.