TRAINING IN MOLECULAR VIROLOGY AND PATHOGENESIS

分子病毒学和发病机制培训

• 批准号: 6786061
• 负责人: Colin R. Parrish
• 金额: $ 13.5万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6786061
• 关键词: TRAINING; MOLECULAR; VIROLOGY; PATHOGENESIS

DESCRIPTION (adapted from the application): The purpose of this program is to provide comprehensive predoctoral training in molecular virology and pathogenesis by coupling a strong foundation in coursework with research experience in broad areas of virology. Support for five predoctoral students, including two DVM students is requested. Trainees entering the program will be selected based upon the strength of their undergraduate (or DVM) backgrounds, research experience in the biological sciences and career goals in the study of virology. All trainees will take virology core courses, various advanced courses in other relevant disciplines such as molecular biology, biochemistry, and immunology, a mandatory course on Ethical Issues and Professional Responsibilities, and they will participate in a seminar series, journal club and research retreat. Graduate- student training will be administered through and research retreat. Graduate- student training will be administered through the Cornell Graduate School - the Fields of Graduate Education Comparative Biomedical Sciences; Microbiology; Biochemistry, Molecular and Cell Biology; and Genetics and Development Thesis research will be performed in one of the eight laboratories of the participating faculty who have primary appointments in the College of Veterinary Medicine, the Department of Molecular Biology and Genetics or the Boyce Thompson Institute. Existing support for the proposed program is substantial in the form of the research environment and facilities, the Cornell Biotechnology Program and computing and library systems. Areas available for training are centered on viral replication and assembly, gene expression and pathogenesis. These studies encompass retroviral, herpesviral and hepadnaviral oncogenesis, retrovirus-induced immunodeficiencies, retroviral RNA packaging and capsid structure and assembly, baculovirus- gene regulation and expression, herpesvirus and influenza virus genome packaging and intracellular transport, parvovirus tropism and capsid crystallographic structure, and herpesvirus and hepadnavirus vaccine and antivirals development. In vivo models of feline, avian, murine, piscine, sciurid, and canine species are available to assess pathogenesis of viral infections.

描述(改编自应用程序)：本程序的目的是 提供全面的分子病毒学博士前培训和 课程与研究相结合的坚实基础的发病机制 在病毒学的广泛领域有经验。资助五名博士后研究生， 要求包括两名DVM学生。参加该计划的实习生将是 根据他们的本科生(或DVM)背景的实力来选择， 在生物科学方面的研究经验和在研究中的职业目标 病毒学。 所有受训人员将参加病毒学核心课程、各种高级课程 其他相关学科，如分子生物学、生物化学和 免疫学，一门关于伦理问题和专业的必修课 责任，他们将参加一个系列研讨会，期刊俱乐部 和研究休养地。研究生培训将通过以下方式进行管理 和研究休养地。研究生培训将通过以下方式进行管理 康奈尔大学研究生院--研究生教育比较领域 生物医学；微生物学；生物化学、分子和细胞生物学； 遗传学和发育论文研究将在其中一个 有初级预约的参与教职员工的八个实验室 在兽医学院，分子生物学和 遗传学或博伊斯·汤普森研究所。现有对提议的支持 计划在研究环境和设施的形式上是实质性的， 康奈尔大学生物技术计划以及计算机和图书馆系统。 可供培训的领域集中在病毒复制和组装方面， 基因表达与发病机制。这些研究包括逆转录病毒， 逆转录病毒诱导的疱疹病毒和肝炎病毒致癌 免疫缺陷、逆转录病毒RNA包装和衣壳结构以及 组装，杆状病毒基因调控和表达，疱疹病毒和 流感病毒基因组包装和细胞内运输，细小病毒 嗜性和衣壳晶体结构，疱疹病毒和 肝炎病毒疫苗和抗病毒药物的开发。在猫的活体模型中， 鸟类、小鼠、鱼类、海狗和犬科动物都可以用来评估 病毒感染的发病机制。