ENTOMOLOGICAL ASSUMPTIONS OF DENGUE CONTROL

登革热控制的昆虫学假设

• 批准号: 6170948
• 负责人: THOMAS WALLACE SCOTT
• 金额: $ 29.32万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6170948
• 关键词: Aedes; animal ecology; animal population density; arthropod borne communicable disease; atmosphere /weather; blood chemistry; communicable disease control; communicable disease transmission; computer simulation; data collection methodology /evaluation; dengue; dengue virus; disease /disorder proneness /risk; disease vectors; enzyme linked immunosorbent assay; field study; human subject; questionnaires; statistics /biometry

DESCRIPTION (Adapted from the applicant's Abstract): Since the abandonment of Aedes aegypti eradication efforts in the late 1960's, the goal of dengue control programs has been to prevent severe forms of disease (DHF/DSS) by reducing mosquito vector populations to levels that significantly lower, but do not eliminate virus transmission. This strategy assumes a quantitative relationship between mosquito densities and intensity of dengue transmission which has never been tested. The objective of this project is to determine the nature of that relationship. That is, to measure directly dengue transmission rates after lowering mosquito population densities to levels between minimum (elimination) and maximum (no effect) thresholds. We will use traditional and novel entomological surveillance techniques to monitor mosquito populations and measure serological conversion against dengue viruses in cohorts of Peruvian school children as an index of dengue transmission. We will characterize the relationship between Ae. aegypti abundance and dengue seroconversion rates with multiple logistic regression analyses. Using entomological data on container type and indices of adult mosquito density and seroprevalence data, we will parameterize a dengue computer simulation model that integrates site specific information on mosquitoes with human age structure, human seroprevalence rates, and weather data. Using the model, we will estimate mosquito density thresholds and the effects of mosquito population reductions on dengue risk. Because, nearly all factors influencing dengue transmission are believed to vary spatially, all data gathered in our study will be indexed geographically. We will use kriging techniques to characterize spatial patterns in parameters and to develop interpolated maps for mosquito abundance and dengue risk. The first 2 years of our study will be devoted to gathering entomological and serological data, indexing geographic information, and characterizing the existing spatial patterns of mosquito abundance and dengue transmission. During subsequent years, we will quantify the effects of vector control interventions on incidence of infection. Our study will (1) be the first to test directly the entomological thresholds of dengue transmission, (2) be the first to examine empirically the relationship between mosquito density and dengue virus transmission, and (3) have direct application to control of dengue worldwide.

描述(改编自申请人摘要)：自被遗弃以来 在20世纪60年代末消灭埃及伊蚊的努力中，S的目标是登革热 控制方案通过以下方式预防严重形式的疾病(DHF/DSS) 将蚊子媒介种群减少到显著降低的水平，但 不要消灭病毒传播。这一战略假定 蚊虫密度与登革热传播强度的关系 它从未被测试过。该项目的目标是确定 这种关系的性质。也就是说，直接测量登革热 将蚊子密度降低到一定水平后的传播率 介于最小(消除)和最大(无影响)阈值之间。我们会 使用传统和新的昆虫学监测技术 蚊子种群和测量登革热的血清学转化率 作为登革热指标的秘鲁学龄儿童队列中的病毒 变速箱。我们将描述Ae.埃及伊蚊 多因素Logistic回归分析登革热抗体滴度与血清转阴率 分析。利用昆虫学数据研究成虫的容器类型和指数 蚊子密度和血清阳性率数据，我们将对登革热进行参数化 集成现场特定信息的计算机模拟模型 蚊子与人类年龄结构、人类血清阳性率和天气 数据。使用该模型，我们将估计蚊子密度阈值和 蚊子数量减少对登革热风险的影响。因为，几乎 所有影响登革热传播的因素都被认为在空间上是不同的， 我们研究中收集的所有数据都将按地理位置编入索引。我们将使用 用于描述参数中的空间模式的克里格法技术 制作蚊子数量和登革热风险的插补地图。第一 我们两年的研究将致力于收集昆虫学和 血清学数据，索引地理信息，并表征 蚊子数量和登革热传播的现有空间格局。 在接下来的几年里，我们将量化病媒控制的影响 关于感染发生率的干预措施。我们的研究将是(1)第一个 直接检测登革热传播的昆虫学阈值，(2) 第一次对蚊子密度和蚊子密度之间的关系进行了实证研究 和登革热病毒的传播，以及(3)有直接应用于控制 世界范围内的登革热。