Measuring Entomological Risk for Dengue

测量登革热的昆虫学风险

• 批准号: 7661641
• 负责人: THOMAS WALLACE SCOTT
• 金额: $ 44.18万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7661641
• 关键词: Accounting; Aedes; Affect; Area; Bite; Blood; Cities; Cohort Studies; Communities; Culicidae; DNA Fingerprinting; Data; Dengue; Dengue Virus; Dimensions; Exposure to; Fever; Frequencies; Goals; Herd Immunity; Home environment; Household; Human; Incidence; Individual; Infection; Interview; Investigation; Knowledge; Location; Longitudinal Studies; Marketing; Measurement; Measures; Movement; Participant; Pattern; Persons; Peru; Population Density; Predictive Value; Prevention program; Probability; Relative (related person); Relative Risks; Research; Research Personnel; Risk; Risk Estimate; Schools; Series; Serotyping; Site; Social Network; Surveillance Program; Techniques; Temperature; Testing; Time; Vaccines; Virus Diseases; Visit; Workplace; base; experience; field study; high risk; indexing; network models; practical application; programs; prospective; residence; transmission process; vector; vector control; vector mosquito

DESCRIPTION (provided by applicant): The impact of human movement patterns on exposure of people to bites from mosquito vectors is a major knowledge gap in the understanding of dengue virus (DV) transmission dynamics. Because Ae. aegypti is a daytime biting mosquito we anticipate that the daytime activity patterns of human hosts will profoundly affect their risk of exposure to infective mosquito bites. Testing these ideas will require identification of operationally feasible measures of entomological risk estimated at an appropriate geographic scale that accounts for movements of susceptible humans in and out of high risk areas. Relative risk of DV infection has never been rigorously measured at the multiple locations that susceptible individual visit during their daily activities; like the homes of neighbors or relatives, schools, markets, workplaces or other communities. In the Amazonian city of Iquitos, Peru where we have over 6 years of Ae. aegypti and dengue research experience we propose to test the hypothesis that spatial dimensions of dengue virus transmission are defined by daily patterns of human movement. We predict that DV incidence rates are positively correlated with the number of bites received from Aedes aegypti at high risk locations, serotype specific herd immunity, and ambient temperature. We intend to test our hypothesis in the context of 2 specific aims. First, a combination of retrospective and prospective cohort studies will be used to determine whether measurement of entomological risk across a person's activity space provides a better prediction of DV infection risk than limiting assessment to their household. Second, we will use DNA profiling of blood in engorged mosquitoes to determine the risk of a person being bitten by Ae. aegypti at different sites across their activity space. Data collected in these field studies will be analyzed using a series of spatial statistical techniques and social network modeling to define the spatial dimensions of DV transmission and the predictive value of entomological surveillance. Our goal is to clarify the value of entomological indices in dengue surveillance programs by defining the spatial dimensions of DV transmission. Our research will be the most definitive test to-date of the empirical relationship between entomological risk and DV transmission. Our results will be relevant for dengue prevention programs based on vector control and/or vaccine strategies and will have immediate, practical applications for dengue surveillance and control worldwide.

描述（由申请人提供）：人类运动模式对人们暴露于蚊虫媒介叮咬的影响是了解登革热病毒（DV）传播动力学的一个主要知识缺口。因为Ae。埃及伊蚊是一种白天叮咬的蚊子，我们预计人类宿主的白天活动模式将深刻影响他们暴露于传染性蚊子叮咬的风险。要检验这些想法，就需要确定可行的昆虫学风险措施，在适当的地理范围内进行估计，并考虑易感人群进出高风险地区的流动。在易感个体日常活动中访问的多个地点，从未严格测量DV感染的相对风险；比如邻居或亲戚的家、学校、市场、工作场所或其他社区。在秘鲁的亚马逊城市伊基托斯，我们有超过6年的Ae。我们建议对埃及伊蚊和登革热研究经验进行检验，以验证登革热病毒传播的空间维度是由人类日常活动模式确定的假设。我们预测，DV的发病率与埃及伊蚊在高危地区的叮咬数量、血清型特异性群体免疫和环境温度呈正相关。我们打算在两个具体目标的背景下检验我们的假设。首先，将采用回顾性和前瞻性队列研究相结合的方法，以确定在一个人的活动空间测量昆虫学风险是否比在其家庭进行限制评估更能预测DV感染风险。其次，我们将使用充血蚊子血液的DNA分析来确定一个人被伊蚊叮咬的风险。埃及伊蚊在它们活动空间的不同地点。本文将利用一系列空间统计技术和社会网络模型对这些实地研究收集的数据进行分析，以确定DV传播的空间维度和昆虫学监测的预测价值。我们的目标是通过定义DV传播的空间维度来阐明昆虫学指数在登革热监测计划中的价值。我们的研究将是迄今为止昆虫学风险与DV传播之间经验关系的最明确测试。我们的研究结果将与基于病媒控制和/或疫苗策略的登革热预防计划相关，并将在全球范围内对登革热监测和控制具有直接的实际应用。