ENTOMOLOGICAL ASSUMPTIONS OF DENGUE CONTROL

登革热控制的昆虫学假设

• 批准号: 6532739
• 负责人: THOMAS WALLACE SCOTT
• 金额: $ 31.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6532739
• 关键词: Aedes; animal ecology; animal population density; arthropod borne communicable disease; atmosphere /weather; blood chemistry; communicable disease control; communicable disease transmission; computer simulation; data collection methodology /evaluation; dengue; dengue virus; disease /disorder proneness /risk; disease vectors; enzyme linked immunosorbent assay; field study; human subject; questionnaires; statistics /biometry

DESCRIPTION (Adapted from the applicant's Abstract): Since the abandonment of Aedes aegypti eradication efforts in the late 1960's, the goal of dengue control programs has been to prevent severe forms of disease (DHF/DSS) by reducing mosquito vector populations to levels that significantly lower, but do not eliminate virus transmission. This strategy assumes a quantitative relationship between mosquito densities and intensity of dengue transmission which has never been tested. The objective of this project is to determine the nature of that relationship. That is, to measure directly dengue transmission rates after lowering mosquito population densities to levels between minimum (elimination) and maximum (no effect) thresholds. We will use traditional and novel entomological surveillance techniques to monitor mosquito populations and measure serological conversion against dengue viruses in cohorts of Peruvian school children as an index of dengue transmission. We will characterize the relationship between Ae. aegypti abundance and dengue seroconversion rates with multiple logistic regression analyses. Using entomological data on container type and indices of adult mosquito density and seroprevalence data, we will parameterize a dengue computer simulation model that integrates site specific information on mosquitoes with human age structure, human seroprevalence rates, and weather data. Using the model, we will estimate mosquito density thresholds and the effects of mosquito population reductions on dengue risk. Because, nearly all factors influencing dengue transmission are believed to vary spatially, all data gathered in our study will be indexed geographically. We will use kriging techniques to characterize spatial patterns in parameters and to develop interpolated maps for mosquito abundance and dengue risk. The first 2 years of our study will be devoted to gathering entomological and serological data, indexing geographic information, and characterizing the existing spatial patterns of mosquito abundance and dengue transmission. During subsequent years, we will quantify the effects of vector control interventions on incidence of infection. Our study will (1) be the first to test directly the entomological thresholds of dengue transmission, (2) be the first to examine empirically the relationship between mosquito density and dengue virus transmission, and (3) have direct application to control of dengue worldwide.

描述（改编自申请人的摘要）：自放弃

项目成果

Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission.

• DOI: 10.1371/journal.pntd.0000670
• 发表时间: 2010-05-04
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Morrison AC;Minnick SL;Rocha C;Forshey BM;Stoddard ST;Getis A;Focks DA;Russell KL;Olson JG;Blair PJ;Watts DM;Sihuincha M;Scott TW;Kochel TJ
• 通讯作者: Kochel TJ

Characteristics of the spatial pattern of the dengue vector, Aedes aegypti, in Iquitos, Peru

• DOI: 10.4269/ajtmh.2003.69.494
• 发表时间: 2003-11-01
• 期刊: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
• 影响因子: 3.3
• 作者: Getis, A;Morrison, AC;Scott, TW
• 通讯作者: Scott, TW

Performance of the tourniquet test for diagnosing dengue in Peru.

在秘鲁进行用于诊断登革热的止血带测试。

• DOI: 10.4269/ajtmh.13-0103
• 发表时间: 2013
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Halsey,EricS;Vilcarromero,Stalin;Forshey,BrettM;Rocha,Claudio;Bazan,Isabel;Stoddard,StevenT;Kochel,TadeuszJ;Casapia,Martin;Scott,ThomasW;Morrison,AmyC
• 通讯作者: Morrison,AmyC