CORE--ANALYTICAL FACILITY /AMINO ACIDS

核心--分析设施/氨基酸

• 批准号: 6314055
• 负责人: PAUL J FLAKOLL
• 金额: $ 11.77万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314055
• 关键词: aminoacid metabolism; analytical chemistry; biomedical facility; clinical research; dietary aminoacid; dietary trace element; dogs; high performance liquid chromatography; human subject; liquid chromatography mass spectrometry; nutrition; nutrition related tag

DESCRIPTION (adapted from the application): The Amino Acid Core Laboratory at Vanderbilt University was established in 1975 as a joint facility supported by the General Clinical Research Center (GCRC) and the Diabetes Research and Training Center (DRTC). The GCRC provided space and professional guidance (Dr. William Lacy), while the DRTC and GCRC jointly provided salary and supply support. In 1984, the Section of Surgical Sciences at Vanderbilt contributed to the further development of the Amino Acid Core laboratory by purchasing new equipment. The Core was organized under the direction of Dr. Naji Abumrad with special emphasis on the use of high performance liquid chromatography (HPLC) to assay amino acids. Dr. Lacy served as a consultant during this period. Over the next few years, new equipment was acquired and methods were developed in response to user demand for the measurement of a variety of labeled and unlabeled amino acids. With Dr. Lacy's untimely death in 1987, and the appointment of a new director of the GCRC, the Amino Acid Core was moved to space within the Section of Surgical Sciences. In 1984, the Vanderbilt CNRU joined the newly reorganized Amino Acid Core laboratory. In 1990, Dr. Paul Flakoll, Assistant Professor of Surgery, was appointed as director of the laboratory. Therefore, over the past 23 years the Amino Acid Core laboratory as evolved into a joint endeavor between the CNRU and the DRTC. This has resulted in greater efficiency, the offering of a wider range of services, and considerable financial savings. During its history, the core has progressed from a laboratory with two primary services (full amino acid profiles and alanine specific radioactivity) and three primary investigators to a laboratory with seventeen different services and sixteen investigators. Therefore, the core laboratory remains as a highly utilized and active component of the CNRU.

描述（改编自申请）：氨基酸核心实验室，位于 范德比尔特大学成立于 1975 年，是一所由以下机构支持的联合大学： 一般临床研究中心 (GCRC) 和糖尿病研究中心 培训中心（DRTC）。 GCRC 提供了空间和专业指导（Dr. William Lacy），而 DRTC 和 GCRC 共同提供工资和供应 支持。 1984 年，范德比尔特大学外科科学部做出了贡献 通过购买新的氨基酸核心实验室进一步发展 设备。该核心是在 Naji Abumrad 博士的指导下组织的 特别强调使用高效液相色谱（HPLC） 测定氨基酸。莱西博士在此期间担任顾问。超过 接下来的几年，购买了新设备并开发了方法 响应用户对各种标记和测量的需求 未标记的氨基酸。随着 Lacy 博士于 1987 年英年早逝， GCRC任命新主任，氨基酸核心转移至 外科科学科内的空间。 1984 年，范德比尔特 CNRU 加入新重组的氨基酸核心实验室。 1990年，保罗博士 Flakoll，外科助理教授，被任命为该中心主任 实验室。因此，在过去的23年里，氨基酸核心实验室作为 发展成为 CNRU 和 DRTC 之间的共同努力。这导致了 提高效率，提供更广泛的服务，以及 节省大量资金。在其历史上，核心不断进步 来自具有两项主要服务（完整的氨基酸谱和 丙氨酸特异性放射性）和实验室的三名主要研究人员 拥有十七个不同的部门和十六名调查员。因此， 核心实验室仍然是 CNRU 的一个高度利用和活跃的组成部分。