CORE--ANALYTICAL FACILITY /AMINO ACIDS

核心--分析设施/氨基酸

• 批准号: 6450312
• 负责人: PAUL J FLAKOLL
• 金额: $ 11.77万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6450312
• 关键词: aminoacid metabolism; analytical chemistry; biomedical facility; clinical research; dietary aminoacid; dietary trace element; dogs; high performance liquid chromatography; human subject; liquid chromatography mass spectrometry; nutrition; nutrition related tag

DESCRIPTION (adapted from the application): The Amino Acid Core Laboratory at Vanderbilt University was established in 1975 as a joint facility supported by the General Clinical Research Center (GCRC) and the Diabetes Research and Training Center (DRTC). The GCRC provided space and professional guidance (Dr. William Lacy), while the DRTC and GCRC jointly provided salary and supply support. In 1984, the Section of Surgical Sciences at Vanderbilt contributed to the further development of the Amino Acid Core laboratory by purchasing new equipment. The Core was organized under the direction of Dr. Naji Abumrad with special emphasis on the use of high performance liquid chromatography (HPLC) to assay amino acids. Dr. Lacy served as a consultant during this period. Over the next few years, new equipment was acquired and methods were developed in response to user demand for the measurement of a variety of labeled and unlabeled amino acids. With Dr. Lacy's untimely death in 1987, and the appointment of a new director of the GCRC, the Amino Acid Core was moved to space within the Section of Surgical Sciences. In 1984, the Vanderbilt CNRU joined the newly reorganized Amino Acid Core laboratory. In 1990, Dr. Paul Flakoll, Assistant Professor of Surgery, was appointed as director of the laboratory. Therefore, over the past 23 years the Amino Acid Core laboratory as evolved into a joint endeavor between the CNRU and the DRTC. This has resulted in greater efficiency, the offering of a wider range of services, and considerable financial savings. During its history, the core has progressed from a laboratory with two primary services (full amino acid profiles and alanine specific radioactivity) and three primary investigators to a laboratory with seventeen different services and sixteen investigators. Therefore, the core laboratory remains as a highly utilized and active component of the CNRU.

描述(改编自申请)：氨基酸核心实验室 范德比尔特大学成立于1975年，是由 综合临床研究中心(GCRC)和糖尿病研究和 培训中心(DRTC)GCRC提供了空间和专业指导(Dr。 William Lacy)，而DRTC和GCRC共同提供工资和供应 支持。1984年，范德比尔特大学外科科学科为 通过购买新产品进一步发展氨基酸核心实验室 设备。核心是在纳吉·阿布勒德博士的指导下组织的， 特别强调使用高效液相色谱(HPLC)来 测定氨基酸。莱西博士在此期间担任顾问。超过了 在接下来的几年里，获得了新的设备，并开发了方法 响应用户的测量需求，测量各种标签和 未标记的氨基酸。1987年莱西博士英年早逝， 任命新的GCRC董事，氨基酸核心被移至 外科科学科内的空间。1984年，范德比尔特CNRU 加入了新重组的氨基酸核心实验室。1990年，保罗博士 外科学助理教授弗拉科尔被任命为该中心主任 实验室。因此，在过去的23年里，氨基酸核心实验室作为 演变成了CNRU和DRTC的共同努力。这导致了 更高的效率，提供更广泛的服务，以及 节省了相当多的资金。在其历史上，核心取得了进步 来自拥有两项主要服务的实验室(完整的氨基酸图谱和 丙氨酸特定放射性)和三名主要研究人员到实验室 有17个不同的部门和16名调查人员。因此， 核心实验室仍然是CNRU的一个高度利用和活跃的组成部分。