CHEMISTRY OF BIOLOGICAL SYSTEMS

生物系统化学

• 批准号: 6150909
• 负责人: BRUCE GANEM
• 金额: $ 20.78万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6150909
• 关键词: CHEMISTRY; BIOLOGICAL; SYSTEMS

This revised proposal describes plans by sixteen Cornell faculty members to establish a vigorous chemistry-biology interface predoctoral training program which is designed to produce scientists having thorough training in several aspects of "pure" chemistry as well as in scientific disciplines such as structural and bioorganic chemistry, drug design, enzymology and molecular biology (to name just a few) which lie at the interface of chemistry and biology. The proposed project focuses sharply on three main features of the chemistry of biological systems: design, assembly and analysis. The purpose of the plan described herein is to help trainees develop beyond the scope of a typical graduate program in chemistry. In addition to having strong undergraduate training in chemistry, the sixteen students selected for support will further advance their interdisciplinary training by planning their graduate academic work around a core curriculum of courses in areas spanning both chemical and biological disciplines. Moreover each will be completely free to carry out his or her doctoral thesis research in one or more of the laboratories of the sixteen participating faculty. All participating faculty have strong research programs in various aspects of chemistry, which are well-funded by the National Institutes of Health. Nine participating faculty have primary academic appointments in the Department of Chemistry, and five of these chemists are elected members of the field of biochemistry. The overall research interests of participating faculty are broadly distributed over areas of synthetic organic, bioorganic, biophysical and polymer chemistry, as well as such fields as x-ray crystallography, nmr spectroscopy, protein structure and function, enzymology and immunology. While individual research groups are extremely well-equipped to conduct the proposed research, Cornell University maintains a large number of diverse instrument facilities and dedicated research centers which are available to all trainees, Besides attending weekly seminars on relevant topics within the Field of Chemistry and the Division of Biological Sciences at Cornell, trainees will participate in a special interdisciplinary seminar program, with monthly meetings during the academic year when both students and faculty present their work. Trainees will also be exposed to industrial research through internships with interested industrial affiliates as well as through campus seminars and visits by industrial scientists. Thesis research and collaborations in the laboratories of the sixteen participating faculty members prepare trainees for careers in multidisciplinary research at the interface of chemistry and biology.

这项修订的提案描述了16名康奈尔教师的计划 建立剧烈的化学生物学接口训练 旨在生产经过彻底培训的科学家的计划 在“纯”化学以及科学的几个方面 诸如结构和生物学化学，药物设计等学科， 酶学和分子生物学（仅举几例） 化学和生物学的界面。拟议的项目急切地关注 关于生物系统化学的三个主要特征：设计， 组装和分析。本文所述的计划的目的是 帮助学员发展超出典型研究生课程的范围 化学。除了接受强大的本科培训 化学，被选为支持的16名学生将进一步进步 通过计划研究生学术工作，他们的跨学科培训 在化学和核心课程的核心课程周围 生物学科。而且，每个都将完全自由携带 在一个或多个 十六位参与教师的实验室。都参加 教师在化学的各个方面都有强大的研究计划， 由美国国立卫生研究院资助大量资金。九 参加教师在 化学系和其中五名化学家是当选成员 生物化学领域。总体研究兴趣 参与教师在合成领域广泛分布 有机，生物有机，生物物理和聚合物化学等 场作为X射线晶体学，NMR光谱，蛋白质结构和 功能，酶学和免疫学。而个别研究小组是 设备齐全的进行拟议的研究，康奈尔 大学维护着大量不同的仪器设施， 专门的研究中心，除了所有学员 参加每周有关该领域相关主题的研讨会 康奈尔大学的化学和生物科学系 将参加特殊的跨学科研讨会计划 学生和教职员工的学年每月会议 介绍他们的作品。学员也将接触工业研究 通过与有兴趣的工业会员的实习以及 通过校园研讨会和工业科学家的访问。论文 16个实验室的研究与合作 参与的教职员工为学员准备职业准备 化学与生物学界面的多学科研究。