ANOREXIA AND WEIGHT LOSS DURING ACUTE INFLAMMATION

描述（改编自研究者摘要）：厌食症和 导致体重明显减轻的加速catalysis是常见的 对创伤性损伤的全身炎症反应的表现， 感染和癌症。 蛋白质的损失转化为组织的损失 功能，因为身体蛋白质没有无活性的储存形式;因此， 炎症期有可能增加发病率， mortality. 关于在体内的相互作用， 促炎细胞因子与其他宿主因子在急性 炎症反应。 这项研究旨在研究 被认为改变能量调节系统的因素之间的相互作用， 急性炎症 这些因子包括促炎细胞因子（IL-1， IL-6和TNF-肿瘤坏死因子），它们被认为抑制正常的 蛋白质能量保存机制和激素参与了 长期能量调节（即胰岛素、瘦素和糖皮质激素）。 将进行性别比较，因为生殖激素可能会起作用 与炎症反应的多种成分协同作用， 增强厌食和减肥。 急性炎症动物模型 将在动物体重正常或已经 实验增加或减少的时间急性炎症是 诱导。 激素和细胞因子与食物的相互关系 关键时间的摄入量、膳食模式、微量营养素选择和体重 雄性和雌性大鼠急性炎症后， 表征了 因为胰岛素、瘦素和糖皮质激素的水平 根据体重，这种方法提供了一种理想的体内方法， 研究性别、激素和细胞因子之间的相互作用， 它们在炎症引起的厌食症中的作用。 这项研究的结果将 提供信息，指导制定干预措施， 增加能量摄入，还能促进维持身体正常 在急性炎症期间的组合物。

DESCRIPTION (Adapted from the Investigator's Abstract): Anorexia and accelerated catabolism leading to marked loss of body weight are common manifestations of the systemic inflammatory response to traumatic injury, infection, and cancer. Loss of protein translates into loss of tissue function because body protein has no inactive storage form; thus, extended periods of inflammation have the potential of increasing morbidity and mortality. Much remains unknown about the in vivo interaction of proinflammatory cytokines with other host factors during the acute inflammatory response. This proposed research seeks to examine the interaction among factors believed to alter energy-regulatory systems during acute inflammation. These factors include proinflammatory cytokines (IL-1, IL-6, and TNF-tumor necrosis factor) which are thought to inhibit normal protein-energy conserving mechanisms, and hormones shown to be involved in long-term energy regulation (namely insulin, leptin, and glucocorticoids). Gender comparison will be made because reproductive hormones may act synergistically with multiple components of the inflammatory response to enhance anorexia and weight loss. An animal model of acute inflammation will be used in which body weight of the animal is normal, or has been experimentally increased or decreased at the time acute inflammation is induced. The interactive relationship of hormones and cytokines to food intake, meal pattern, micronutrient selection, and body weight at key time points following acute inflammation in male and female rats will be characterized. Because insulin, leptin, and glucocorticoid levels vary according to body weight, this approach provides an ideal in vivo method for studying the interaction among gender, hormones, and cytokines to determine their roles in inflammation-induced anorexia. Results of this research will provide information to guide the development of interventions that not only increase energy intake, but also promote maintenance of normal body composition during acute inflammation.