ANOREXIA AND WEIGHT LOSS DURING ACUTE INFLAMMATION

描述(改编自《调查者摘要》)：厌食症和 加速分解代谢导致体重显著减轻是很常见的。 创伤后全身炎症反应的表现， 感染和癌症。蛋白质的损失会转化为组织的损失 功能，因为身体蛋白质没有非活性的存储形式；因此，扩展了 发炎时期有可能增加发病率和 死亡率。在体内的相互作用仍有许多未知之处。 促炎细胞因子与其他宿主因子在急性发作中的作用 炎症反应。这项拟议的研究试图检查 被认为改变能源监管系统的因素之间的相互作用 急性炎症。这些因子包括促炎细胞因子(IL-1， IL-6和肿瘤坏死因子)，它们被认为可以抑制正常 蛋白质能量守恒机制和荷尔蒙被证明参与了 长期的能量调节(即胰岛素、瘦素和糖皮质激素)。 将进行性别比较，因为生殖激素可能会起作用 与炎症反应的多种成分协同作用 增强厌食症和减肥效果。急性炎症的动物模型 会用在体重正常的动物身上，或者已经 在实验中增加或减少急性炎症时 诱导性。激素和细胞因子与食物的相互作用关系 摄入量、膳食模式、微量营养素选择和关键时间的体重 雄性和雌性大鼠急性炎症后的穴位 特色化的。因为胰岛素、瘦素和糖皮质激素水平各不相同 根据体重，这种方法提供了一种理想的体内方法 研究性别、激素和细胞因子之间的相互作用以确定 它们在炎症引起的厌食症中的作用。这项研究的结果将 提供信息以指导制定干预措施，不仅是 增加能量摄入，还能促进维持身体正常 急性炎症期间的成分。

DESCRIPTION (Adapted from the Investigator's Abstract): Anorexia and accelerated catabolism leading to marked loss of body weight are common manifestations of the systemic inflammatory response to traumatic injury, infection, and cancer. Loss of protein translates into loss of tissue function because body protein has no inactive storage form; thus, extended periods of inflammation have the potential of increasing morbidity and mortality. Much remains unknown about the in vivo interaction of proinflammatory cytokines with other host factors during the acute inflammatory response. This proposed research seeks to examine the interaction among factors believed to alter energy-regulatory systems during acute inflammation. These factors include proinflammatory cytokines (IL-1, IL-6, and TNF-tumor necrosis factor) which are thought to inhibit normal protein-energy conserving mechanisms, and hormones shown to be involved in long-term energy regulation (namely insulin, leptin, and glucocorticoids). Gender comparison will be made because reproductive hormones may act synergistically with multiple components of the inflammatory response to enhance anorexia and weight loss. An animal model of acute inflammation will be used in which body weight of the animal is normal, or has been experimentally increased or decreased at the time acute inflammation is induced. The interactive relationship of hormones and cytokines to food intake, meal pattern, micronutrient selection, and body weight at key time points following acute inflammation in male and female rats will be characterized. Because insulin, leptin, and glucocorticoid levels vary according to body weight, this approach provides an ideal in vivo method for studying the interaction among gender, hormones, and cytokines to determine their roles in inflammation-induced anorexia. Results of this research will provide information to guide the development of interventions that not only increase energy intake, but also promote maintenance of normal body composition during acute inflammation.